Expression of nestin, mesothelin and epithelial membrane antigen (EMA) in developing and adult human meninges and meningeomas
| Autor: | Ljerka Ostojić, Mirna Saraga-Babić, Katarina Vukojević, Joško Petričević, Simun Andjelinovic, Gea Forempoher, Snjezana Mardesic-Brakus |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Pathology
medicine.medical_specialty Histology endocrine system diseases Population Nerve Tissue Proteins GPI-Linked Proteins Nestin Meningioma Meninges Intermediate Filament Proteins human development meninges meningeomas nestin mesothelin epithelial membrane antigen Meningeal Neoplasms medicine Humans Neoplastic transformation Meningeal Neoplasm Mesothelin education education.field_of_study biology Mucin-1 Cell Biology General Medicine medicine.disease Immunohistochemistry Epithelium medicine.anatomical_structure biology.protein |
| Popis: | The spatial and temporal pattern of appearance of nestin, epithelial membrane antigen (EMA) and mesothelin proteins was immunohistochemically determined in the cells of normal developing and adult human meninges and meningiomas. Human meninges developed as two mesenchymal condensations in the head region. The simple squamous epithelium on the surface of leptomeninges developed during mesenchymal to epithelial transformation. Nestin appeared for the first time in week 7, EMA in week 8, while mesothelin appeared in week 22 of development. In the late fetal period and after birth, nestin expression decreased, whereas expression of EMA and mesothelin increased. EMA appeared in all surface epithelial cells and nodules, while mesothelin was found only in some of them. In adult meninges, all three proteins were predominantly localized in the surface epithelium and meningeal nodules. In meningothelial meningiomas (WHO grade I), EMA was detected in all tumor cells except in the endothelial cells, mesothelin characterized nests of tumor cells, while nestin was found predominantly in the walls of blood vessels. The distribution pattern of those proteins in normal meningeal and tumor cells indicates that nestin might characterize immature cells, while EMA and mesothelin appeared in maturing epithelial cells. Neoplastic transformation of these specific cell lineages contributes to the cell population in meningiomas. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|