Achieving directed immunostimulating complexes incorporation
| Autor: | Christin Andersson, Mikaela Friedman, Anna Lundén, Maria Wikman, Sunan Pinitkiatisakul, Karin Lövgren-Bengtsson, Stefan Ståhl |
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| Rok vydání: | 2006 |
| Předmět: |
Lipoproteins
Recombinant Fusion Proteins medicine.medical_treatment Immunology Biotin Context (language use) Computational biology Biology law.invention Immune system Bacterial Proteins Antigen law Drug Discovery medicine Animals Antigens Pharmacology ISCOM Fusion protein Immunostimulating Complexes Vaccines Subunit Recombinant DNA Molecular Medicine Peptides Adjuvant ISCOMs |
| Zdroj: | Expert Review of Vaccines. 5:395-403 |
| ISSN: | 1744-8395 1476-0584 |
| DOI: | 10.1586/14760584.5.3.395 |
| Popis: | In recent years, several studies have been reported with the common aim of generating general expression systems for straightforward production and subsequent coupling of expressed antigens to an adjuvant system. Here, we describe a series of such efforts with a common theme of using gene fusion technology for association of recombinant antigens to immunostimulating complexes (iscoms). In the early stages of vaccine development, uniform antigen preparations are crucial to allow the comparison of immune responses to different antigens, or even subdomains thereof, and we believe that the described systems constitute an important development in this context. |
| Databáze: | OpenAIRE |
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