De Novo Generation of Singlet Oxygen and Ammine Ligands by Photoactivation of a Platinum Anticancer Complex
| Autor: | Huilin Li, Jennifer S. Butler, Nicola J. Farrer, Yao Zhao, Peter J. Sadler, Abraha Habtemariam, Ruth J. McQuitty, Fuyi Wang |
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| Rok vydání: | 2013 |
| Předmět: |
RM
Guanine Nitrene chemistry.chemical_element Antineoplastic Agents Ligands Photochemistry 010402 general chemistry Oxygen 01 natural sciences antitumor agents Catalysis bioinorganic chemistry chemistry.chemical_compound Pyridine QD Platinum Singlet Oxygen Singlet oxygen Methylamine 010405 organic chemistry Bioinorganic chemistry General Chemistry General Medicine Communications 3. Good health 0104 chemical sciences chemistry photoactivation guanine oxidation Oxidation-Reduction |
| Zdroj: | Angewandte Chemie (International Ed. in English) |
| ISSN: | 0044-8249 1433-7851 |
| DOI: | 10.1002/ange.201307505 |
| Popis: | Worth the excitement: Highly reactive oxygen and nitrogen species are generated by photoactivation of the anticancer platinum(IV) complex trans,trans,trans-[Pt(N3 )2 (OH)2 (MA)(Py)] (MA=methylamine, Py=pyridine). Singlet oxygen is formed from the hydroxido ligands and not from dissolved oxygen, and ammine ligands are products from the conversion of azido ligands to nitrenes. Both processes can induce oxidation of guanine. |
| Databáze: | OpenAIRE |
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