Induction of BAALC and down regulation of RAMP3 in astrocytes treated with differentiation inducers
| Autor: | Neelam Shirsat, Madhavi S. Moodbidri |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_treatment
Down-Regulation Biology Receptor Activity-Modifying Protein 3 Receptor Activity-Modifying Proteins Rats Sprague-Dawley Paracrine signalling medicine Cyclic AMP Staurosporine Animals Dimethyl Sulfoxide RNA Messenger Autocrine signalling Protein kinase C BAALC Growth factor Gene Expression Profiling Intracellular Signaling Peptides and Proteins Membrane Proteins Cell Differentiation Cell Biology General Medicine Neural stem cell Cell biology Neoplasm Proteins Rats Up-Regulation medicine.anatomical_structure Astrocytes Cancer research Astrocyte medicine.drug |
| Zdroj: | Cell biology international. 30(3) |
| ISSN: | 1065-6995 |
| Popis: | Genes controlling proliferation and differentiation of astrocytes are likely to play an important role in the pathogenesis of astrocytic gliomas and could serve as therapeutic targets. mRNA differential display analysis identified two genes, viz. BAALC and RAMP3, whose expression is altered in primary astrocytes treated with differentiation inducers. BAALC, which has been reported to be expressed in neural progenitor cells, was found to be up regulated in both normal and malignant astrocytes on inhibition of proliferation. RAMP3 functions as a modulator of the receptor for adrenomedullin (AM). AM has been suggested to act as autocrine/paracrine growth factor for gliomas. Our studies show RAMP3 down regulation on staurosporine treatment of astrocytes, suggesting protein kinase C inhibition as a possible strategy for inhibiting AM activity and thereby growth of glioma cells. |
| Databáze: | OpenAIRE |
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