Early identification of acute kidney injury in Russell’s viper (Daboia russelii) envenoming using renal biomarkers
| Autor: | Indika Gawarammana, Nicholas A. Buckley, Kalana Maduwage, Indira Ratnayake, Mahesh Munasinghe, Shaluka Jayamanne, Geoffrey K. Isbister, Dhammika Menike Dissanayake, Fahim Mohamed, Umesh Chathuranga, Zoltan H. Endre |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Time Factors Physiology RC955-962 Snake Bites Urine Lipocalin Toxicology Pathology and Laboratory Medicine urologic and male genital diseases Biochemistry Gastroenterology chemistry.chemical_compound 0302 clinical medicine Arctic medicine. Tropical medicine Medicine and Health Sciences Toxins Snakebite Prospective Studies Prospective cohort study biology Acute kidney injury Eukaryota Snakes Acute Kidney Injury Middle Aged Squamates female genital diseases and pregnancy complications Body Fluids 3. Good health Infectious Diseases Creatinine Vertebrates Biomarker (medicine) Female Anatomy Public aspects of medicine RA1-1270 Research Article Neglected Tropical Diseases Adult medicine.medical_specialty VIPeR Adolescent Vipers Toxic Agents 030231 tropical medicine Viper Venoms Risk Assessment Young Adult 03 medical and health sciences Internal medicine medicine Animals Humans Russell's Viper Aged Venoms business.industry Organisms Public Health Environmental and Occupational Health Biology and Life Sciences Reptiles Kidneys Renal System Tropical Diseases medicine.disease 030104 developmental biology chemistry Cystatin C Amniotes biology.protein business Biomarkers |
| Zdroj: | PLoS Neglected Tropical Diseases, Vol 13, Iss 7, p e0007486 (2019) PLoS Neglected Tropical Diseases |
| ISSN: | 1935-2735 |
| DOI: | 10.1371/journal.pntd.0007486 |
| Popis: | Background Acute kidney injury (AKI) is a major complication of snake envenoming, but early diagnosis remains problematic. We aimed to investigate the time course of novel renal biomarkers in AKI following Russell’s viper (Daboia russelii) bites. Methodology/Principal findings We recruited a cohort of patients with definite Russell’s viper envenoming and collected serial blood and urine samples on admission ( Author summary Snake envenoming is a neglected tropical disease that causes death and severe effects in the rural tropics. Acute kidney injury is a major cause of morbidity in snake envenoming, but continues to be poorly recognised and early diagnosis is difficult. We aimed to investigate the time course of renal biomarkers in acute kidney injury, following Russell’s viper (Daboia russelii) envenoming. In a group of 65 definite Russell’s viper bites in Sri Lanka, acute kidney injury was common and sometimes severe. The severity of the acute kidney injury was associated with the blood venom concentrations. Three novel biomarkers, serum cystatin C, urine neutrophil gelatinase-associated lipocalin and urine clusterin became abnormal before serum creatinine, the current standard biomarker for kidney injury. These three novel biomarkers will be useful to diagnose snake envenoming and acute kidney injury. They provide insight into the time course of snakebite associated acute kidney injury. |
| Databáze: | OpenAIRE |
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