Value of 18F-FDG PET/CT in patients with hepatic metastatic carcinoma of unknown primary
| Autor: | Yuekai Li, Lili Qu, Fengcai Li, Xin Li, Jiankui Han |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Sensitivity and Specificity Diagnostic Accuracy Study fluorodeoxyglucose Metastatic carcinoma 03 medical and health sciences 0302 clinical medicine positron emission tomography/computerized tomography Fluorodeoxyglucose F18 Predictive Value of Tests Positron Emission Tomography Computed Tomography medicine Humans In patient 030212 general & internal medicine Neoplasm Metastasis Aged Retrospective Studies Aged 80 and over medicine.diagnostic_test business.industry Carcinoma Liver Neoplasms Case-control study Retrospective cohort study General Medicine Middle Aged medicine.disease Primary tumor hepatic metastatic carcinoma of unknown primary Positron emission tomography 030220 oncology & carcinogenesis Predictive value of tests Case-Control Studies Unknown primary Neoplasms Unknown Primary Female Radiopharmaceuticals Nuclear medicine business Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Purpose This retrospective study aimed to investigate the clinical value of -deoxy-2-(18F)-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in detecting primary lesions of hepatic metastases. Methods A total of 124 patients with hepatic metastatic carcinoma of unknown primary underwent whole body 18F-FDG PET/CT imaging. According to the final diagnoses for both primary sites and hepatic metastases that were confirmed either histopathologically or by clinical follow up, all patients were divided into 4 groups: a true positive group (TP, 95 cases), a false positive group (FP, 9), a true negative group (TN, 8) and a false negative group (FN, 12). Results The TP rate of primary lesions, detected by 18F-FDG PET/CT, was 76.61%, the FP rate 7.26%, the TN rate 6.45% and the FN rate 9.68%. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 18F-FDG PET/CT in the detection of primary tumors were 88.78%, 52.94%, 91.35%, 40%, and 83.06%, respectively. Accurate diagnosis groups (TP, TN) showed a significantly higher SUVmax (standard uptake maximum value) level than that in error diagnosis groups (FP, FN). The SUVmax between hepatic metastases and primary lesions had a positive correlation. The primary tumor sites of hepatic metastases were mainly located in the gastrointestinal organs and the lungs. Conclusions Whole body 18F-FDG PET/CT imaging was sensitive for detecting primary sites/lesions with hepatic metastatases of unknown primary, especially when the SUVmax of hepatic metastases were greater than 4.7. |
| Databáze: | OpenAIRE |
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