Supplementary from RNF126 as a Biomarker of a Poor Prognosis in Invasive Breast Cancer and CHEK1 Inhibitor Efficacy in Breast Cancer Cells

Autor: Junran Zhang, Zhefu Ma, Keri Ruth, Chunhong Yan, Yan Xu, Hongbing Wang, Ceshi Chen, Shunqiang Li, Shanhuai Ma, Shashank Gorityala, Pengyan Fa, Yao Zhang, Zhanwen Du, Zhaojun Qiu, You Pan, Xiaosong Yang
Rok vydání: 2023
Popis: Supplementary Table S1. Association between RNF126 protein expression and clinicopathological parameters in invasive BC. Supplementary Table S2. RNF126 expression and clinicopathologic variables of invasive BC Supplementary Fig. S1. Cell cycle distribution. Supplementary Fig. S2. RNF126 controls CHK1 expression via a direct interaction with E2F1. Supplementary Fig.S3. RNF126 facilitated Cyclin E expression. Supplementary Fig. S4. CHK1 inhibition decreased cell numbers at a greater level in parental cells, compared to cells depleted of RNF126. Supplementary Fig.S5. CHK1 inhibition promoted cell apoptosis and blocked mitotic entry, particularly in cells expressing RNF126. Supplementary Fig.S6. ATR inhibition decreased parental cell numbers and increased replication stress at a greater level, compared to cells depleted of RNF126. Supplementary Fig. S7. CHK1 inhibition upregulates replication stress, particularly in cells with intact RNF126. Supplementary Fig.S8 Representative images of replication tracks from MCF7 cells treated with or without LY2603618 (5 μM).
Databáze: OpenAIRE