Effect of 4.5S RNA depletion on Escherichia coli protein synthesis and secretion
| Autor: | Stanley Brown, Steen Pedersen, C G Jensen |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
chemistry.chemical_classification
Escherichia coli Proteins Peptide Chain Elongation Translational RNA Peptide Ribosomal RNA Biology medicine.disease_cause Microbiology RNA Bacterial Secretory protein Bacterial Proteins chemistry Biochemistry Protein Biosynthesis Heat shock protein Escherichia coli Protein biosynthesis medicine Secretion Signal Recognition Particle Molecular Biology Heat-Shock Proteins Research Article |
| Zdroj: | Journal of Bacteriology. 176:2502-2506 |
| ISSN: | 1098-5530 0021-9193 |
| DOI: | 10.1128/jb.176.9.2502-2506.1994 |
| Popis: | We examined the synthesis of individual proteins following depletion of 4.5S RNA by using a strain deficient in the induction of heat shock proteins. We found that initially the synthesis of all proteins was equally affected, and the peptide elongation rate was reduced by approximately 10%. For up to 1 generation time after the onset of inhibition of total protein synthesis, the processing of secreted proteins was unaffected. After further depletion of 4.5S RNA, accumulation of precursors of secreted proteins was observed under some growth conditions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|