Verongamine, a novel bromotyrosine-derived histamine H3-antagonist from the marine sponge Verongula gigantea

Autor:	Mahesh J. Patel, Ronald Mierzwa, Michael A. Conover, Arthur King, Shirley A. Pomponi, Stephen J. Coval, Salvatore Tozzi, Mohindar S. Puar
Rok vydání:	1994
Předmět:	Magnetic Resonance Spectroscopy Guinea Pigs Histamine Antagonists Pharmaceutical Science Fractionation Pharmacognosy In Vitro Techniques Spectrometry Mass Fast Atom Bombardment Clonidine Analytical Chemistry chemistry.chemical_compound Verongula gigantea Drug Discovery Oximes Animals Pharmacology Chromatography biology Organic Chemistry Antagonist Biological activity Muscle Smooth biology.organism_classification Porifera Sponge Complementary and alternative medicine chemistry Molecular Medicine Tyrosine Histamine H3 receptor Histamine Muscle Contraction
Zdroj:	Journal of natural products. 57(1)
ISSN:	0163-3864
Popis:	The novel bromotyrosine derivative verongamine [1] has been isolated from the marine sponge Verongula gigantea. The isolation of verongamine was facilitated by employing histamine-H3 bioassay-guided fractionation. Verongamine is a specific histamine-H3 antagonist at concentrations as low as 1 microgram/ml.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4127c4e5e3ba5cc026e1bdbafe9c4a70 https://pubmed.ncbi.nlm.nih.gov/8158162 Zobrazit plný text záznamu