Metabolic fiber types of snake transversus abdominis muscle
| Autor: | R. S. Wilkinson, P. M. Nemeth |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Physiology
ATPase Dehydrogenase Oxidative phosphorylation Malate dehydrogenase Tonic (physiology) chemistry.chemical_compound Oxygen Consumption Species Specificity Malate Dehydrogenase Lactate dehydrogenase Myosin medicine Animals Humans L-Lactate Dehydrogenase biology Muscles Adenylate Kinase Snakes Cell Biology Microscopy Electron Biochemistry chemistry biology.protein medicine.symptom Glycolysis Muscle Contraction Muscle contraction |
| Zdroj: | American Journal of Physiology-Cell Physiology. 256:C1176-C1183 |
| ISSN: | 1522-1563 0363-6143 |
| DOI: | 10.1152/ajpcell.1989.256.6.c1176 |
| Popis: | Fibers of the garter snake transversus abdominis muscle fall into three classes according to contraction speed: faster and slower twitch and tonic. To determine the relationship between these physiologically determined classes and established mammalian fiber types, individual fibers were assayed for key enzymes representing the major energy-generating pathways in vertebrate muscle. Five such enzymes were examined: lactate dehydrogenase, malate dehydrogenase, adenylokinase, fumarate hydratase, and beta-hydroxyacyl-CoA dehydrogenase. The muscle contained three principal metabolic fiber types. Fast-contracting twitch fibers had low-oxidative but high-glycolytic capacity and therefore resembled mammalian-type fast-twitch glycolytic (FG) fibers. Slower twitch fibers were high oxidative-high glycolytic, similar to mammalian-type fast-twitch, oxidative, glycolytic (FOG) fibers. Tonic fibers were high oxidative-low glycolytic; this metabolic profile is characteristic of type slow-twitch oxidative (SO) fibers in mammals. Activity of the enzyme adenylokinase, which in mammals correlates with contraction speed and myosin adenosine triphosphatase (ATPase) activity, separated these reptilian fibers into three groups that are similar but not identical to those delineated by oxidative and glycolytic enzymes. Adenylokinase and beta-hydroxyacyl-CoA dehydrogenase showed the widest range of activities in snake muscle and, therefore, the greatest ability to discriminate fiber types. |
| Databáze: | OpenAIRE |
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