Unusual primary ocular neoplasm in a child: leiomyosarcoma of the ciliary body
| Autor: | Mariana M. Cajaiba, Isabela Werneck da Cunha, Martha Motono Chojniak |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Leiomyosarcoma
Uveal Neoplasms Pathology medicine.medical_specialty Enucleation Uveal Neoplasm Biology Cell morphology Eye Enucleation Pathology and Forensic Medicine Diagnosis Differential Ciliary body medicine Atypia Biomarkers Tumor Humans Child Melanoma Cell Proliferation Choroid Ciliary Body Anatomy General Medicine medicine.disease Immunohistochemistry medicine.anatomical_structure Primary Leiomyosarcoma Pediatrics Perinatology and Child Health Female |
| Zdroj: | Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. 11(6) |
| ISSN: | 1093-5266 |
| Popis: | Primary uveal-tract neoplasms are extremely rare in childhood; the most common lesions found are melanocytic. We report here the case of a 7-year-old girl who underwent enucleation of the right eye with clinical suspicion of choroid melanoma as a result of a ciliary body mass that extended to the posterior chamber. Histologically, the neoplasm featured spindle cell morphology, atypia, and mitoses. The tumor expressed smooth muscle α actin, pan-actin HHF-35, and desmin, whereas immunohistochemistry for melanocytic markers, such as S-100, Melan-A, and HMB-45, was negative. Based on these features, the diagnosis of leiomyosarcoma of the ciliary body was firmly established. Although several leiomyomas have been reported in the literature, there are only 2 previously reported cases of primary leiomyosarcoma of the uveal tract. Immunohistochemical expression of muscle proteins allowed distinction from the most common melanocytic tumors arising in this location. |
| Databáze: | OpenAIRE |
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