Wound healing at adaptation zones of skin flaps harvested from acute burned skin
| Autor: | Cagri A. Uysal, Tugrul Maral, Mehmet Haberal, Hüseyin Borman, Gurler Akinbingol, Handan Ozdemir, Suna Turkoglu |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Skin flap Neovascularization Physiologic Critical Care and Intensive Care Medicine Transplant Donor Site Surgical Flaps Burned skin Hydroxyproline chemistry.chemical_compound Medicine Animals Rats Wistar Myofibroblasts Analysis of Variance Wound Healing business.industry Epithelial Cells General Medicine Distal margin Thermal burn Surgery Rats Disease Models Animal chemistry Incision Site Acute Disease Emergency Medicine Thermal damage Collagen Wound healing business Burns |
| Zdroj: | Burns : journal of the International Society for Burn Injuries. 39(6) |
| ISSN: | 1879-1409 |
| Popis: | Background Early reconstruction of burn defects culminates in more successful results. The wound healing process of the burned skin affects not only the curative phase of the burned area but also result of any reconstructive procedure including the regional flaps. Thus, in this study, we have evaluated the wound healing process at the distal incisions of random-pattern skin flaps prepared from burned dorsal skin of rats. Materials and methods Thermal burn damage was performed with dimensions of 3 cm × 3 cm on Wistar albino rats. In group 1 (n = 12), no burn was produced and 3 cm × 3 cm caudally based, random-pattern skin flaps were elevated. In group 2 (n = 12), a 5 cm × 5 cm area of partial-thickness thermal damage was produced and after three days a 3 cm × 3 cm random-pattern skin flap was elevated as in group 1 inside the burned skin site. In group 3 (n = 12), 3 cm × 3 cm area of partial-thickness thermal damage was produced and after three days 3 cm × 3 cm random-pattern skin flap was elevated. In group 4 (n = 12), 3 cm × 3 cm area of partial-thickness thermal damage was produced and after three days a 3 cm × 3 cm random-pattern skin flap was elevated at the distal margin of the burned area. The flaps were adapted to the donor sites in all groups. The histopathological evaluation was done and hydroxyproline levels were measured. Results There were no significant differences between groups regarding presence of epithelialization, myofibroblast numbers, and collagen texture (p > 0.05). Neovascularization level was significantly higher in group 2 than the other groups (p 0.05). Conclusion The preference of the incision site in a burn zone while designing a flap during the acute burn period was proposed to possess no difference in terms of wound healing in an animal model. |
| Databáze: | OpenAIRE |
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