Bisdemethoxycurcumin protects against renal fibrosis via activation of fibroblast apoptosis
| Autor: | Ying Jin, Jiangxia Du, Ziying Zhao, Bo Yang, Liyu Jiang, Fuquan Jin, Peihua Luo, Qiaojun He, Ying Zhang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Curcumin Apoptosis Kidney Protective Agents urologic and male genital diseases Cell Line Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pharmacotherapy Diarylheptanoids In vivo Bisdemethoxycurcumin medicine Renal fibrosis Animals Humans Renal Insufficiency Chronic Urinary Tract Pharmacology Biological Products business.industry Therapeutic effect Fibroblasts Fibrosis In vitro Disease Models Animal 030104 developmental biology chemistry Mechanism of action Cancer research Female medicine.symptom business 030217 neurology & neurosurgery Ureteral Obstruction |
| Zdroj: | European Journal of Pharmacology. 847:26-31 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/j.ejphar.2019.01.012 |
| Popis: | Renal fibrosis is the common final outcome of nearly all progressive chronic kidney diseases (CKD) that eventually develop into end-stage renal failure, which threatens the lives of patients. Currently, there are no effective drugs for the treatment of renal fibrosis. However, studies have shown that certain plant natural products have a fibrosis-alleviating effect. Thus, we have screened a large number of natural products for their ability to protect against renal fibrosis and found that bisdemethoxycurcumin has a good therapeutic effect in renal fibrosis according to the data obtained in a mouse model of unilateral ureteral obstruction (UUO). The results indicate that bisdemethoxycurcumin can efficiently attenuate renal fibrosis induced by UUO. Additional studies of the bisdemethoxycurcumin mechanism of action in the treatment of renal fibrosis demonstrated that the therapeutic effect of bisdemethoxycurcumin is mediated by the specific induction of fibroblast apoptosis at a concentration of 20 μM. bisdemethoxycurcumin can efficiently protect against renal fibrosis both in vitro and in vivo. This discovery will provide new ideas for renal fibrosis treatment in clinics and a new direction for the development of effective drug therapy of renal fibrosis. |
| Databáze: | OpenAIRE |
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