Growth in foetal life and infancy is associated with abdominal adiposity at the age of 2 years: The Generation R Study
| Autor: | Büşra Durmuş, Albert Hofman, Dennis O. Mook-Kanamori, Susanne Holzhauer, Vincent W. V. Jaddoe, Eline M. van der Beek, Guenther Boehm, Eric A.P. Steegers |
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| Přispěvatelé: | Epidemiology, Erasmus MC other, Pediatrics, Obstetrics & Gynecology |
| Rok vydání: | 2010 |
| Předmět: |
Adult
medicine.medical_specialty Birth weight Endocrinology Diabetes and Metabolism Abdominal Fat Gestational Age Weight Gain Cohort Studies Fetal Development Endocrinology SDG 3 - Good Health and Well-being Pregnancy Internal medicine medicine Birth Weight Humans Prospective Studies Adiposity business.industry Body Weight Infant Newborn Gestational age Infant medicine.disease Obesity medicine.anatomical_structure Child Preschool Linear Models Abdomen Generation R Female medicine.symptom business Body mass index Weight gain Maternal Age |
| Zdroj: | Clinical Endocrinology, 72(5), 633-640. Wiley-Blackwell Publishing Ltd |
| ISSN: | 0300-0664 |
| Popis: | P>Objective Early weight gain is associated with an increased risk of obesity. It is not known whether rapid weight gain in foetal life and infancy is also associated with increased abdominal adiposity. We examined the associations of foetal and postnatal growth characteristics with abdominal fat mass at the age of 2 years. Design This study was performed in 481 children participating in a prospective cohort study from early foetal life onward. Measurements Foetal and postnatal growth characteristics in second and third trimester, at birth and at the age of 2 years were related to abdominal fat mass (subcutaneous distance and area, preperitoneal distance and area) measured by ultrasound at the age of 2 years. Results Foetal and birth weight were not associated with abdominal subcutaneous fat mass. Estimated foetal weight in second trimester of pregnancy was inversely associated with preperitoneal fat area [-3 center dot 73% (95% confidence interval -7 center dot 23, -0 center dot 10)] per standard deviation score increase in weight. Weight gain from birth to the age of 2 years was positively associated with preperitoneal fat mass measures. These associations remained significant after adjustment for age, sex, breastfeeding and body mass index. Positive associations were found between catch-up growth in weight and abdominal fat mass measures. Conclusions Our results suggest that rapid growth rates during foetal life and infancy are associated with increased abdominal subcutaneous and preperitoneal fat mass in healthy children. Further studies need to explore whether these associations persist in later life and are related to metabolic syndrome outcomes. |
| Databáze: | OpenAIRE |
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