Both Traditional and Stair Climbing–based HIIT Cardiac Rehabilitation Induce Beneficial Muscle Adaptations
| Autor: | Steve Baker, Emily C. Dunford, Maureen J. MacDonald, Changhyun Lim, Stuart M. Phillips, Chris McGlory, Sara Y. Oikawa, Sydney E. Valentino |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A medicine.medical_specialty Nitric Oxide Synthase Type III medicine.medical_treatment Physical Therapy Sports Therapy and Rehabilitation Coronary Artery Disease High-Intensity Interval Training Interval training Mitochondrial Proteins Coronary artery disease 03 medical and health sciences 0302 clinical medicine Exercise program Internal medicine Heart rate medicine Humans Orthopedics and Sports Medicine Lack of knowledge Phosphorylation Muscle Skeletal Aged Cardiac Rehabilitation Rehabilitation business.industry Microcirculation Stair climbing Skeletal muscle 030229 sport sciences Middle Aged medicine.disease Adaptation Physiological Stair Climbing medicine.anatomical_structure Cardiology Female business |
| Zdroj: | Medicine & Science in Sports & Exercise. 53:1114-1124 |
| ISSN: | 1530-0315 0195-9131 |
| DOI: | 10.1249/mss.0000000000002573 |
| Popis: | PURPOSE There is a lack of knowledge as to how different exercise-based cardiac rehabilitation programming affects skeletal muscle adaptations in coronary artery disease (CAD) patients. We first characterized the skeletal muscle from adults with CAD compared with a group of age- and sex-matched healthy adults. We then determined the effects of a traditional moderate-intensity continuous exercise program (TRAD) or a stair climbing-based high-intensity interval training program (STAIR) on skeletal muscle metabolism in CAD. METHODS Sixteen adults (n = 16, 61 ± 7 yr), who had undergone recent treatment for CAD, were randomized to perform (3 d·wk-1) either TRAD (n = 7, 30 min at 60%-80% of peak heart rate) or STAIR (n = 9, 3 × 6 flights) for 12 wk. Muscle biopsies were collected at baseline in both CAD and healthy controls (n = 9), and at 4 and 12 wk after exercise training in CAD patients undertaking TRAD or STAIR. RESULTS We found that CAD had a lower capillary-to-fiber ratio (C/Fi, 35% ± 25%, P = 0.06) and capillary-to-fiber perimeter exchange (CFPE) index (23% ± 29%, P = 0.034) in Type II fibers compared with healthy controls. However, 12 wk of cardiac rehabilitation with either TRAD or STAIR increased C/Fi (Type II, 23% ± 14%, P < 0.001) and CFPE (Type I, 10% ± 23%, P < 0.01; Type II, 18% ± 22%, P = 0.002). CONCLUSION Cardiac rehabilitation via TRAD or STAIR exercise training improved the compromised skeletal muscle microvascular phenotype observed in CAD patients. |
| Databáze: | OpenAIRE |
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