Role of Oxytocin and Vasopressin in Neuropsychiatric Disorders: Therapeutic Potential of Agonists and Antagonists
| Autor: | Georgina M. Renard, Macarena Moreno, Valeska S. Cid-Jofré, Miguel Reyes-Parada |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Vasopressin
endocrine system Vasopressins vasopressin QH301-705.5 media_common.quotation_subject Drug Agonism Central nervous system Neuropeptide Review Catalysis Inorganic Chemistry Central Nervous System Diseases Oxytocics oxytocin neuropsychiatry disorders Animals Humans Vasoconstrictor Agents Medicine Physical and Theoretical Chemistry Biology (General) Receptor Molecular Biology QD1-999 Spectroscopy media_common antagonists business.industry Mental Disorders Addiction Organic Chemistry neuropeptides General Medicine medicine.disease Computer Science Applications Chemistry medicine.anatomical_structure Oxytocin Schizophrenia Autism agonists pharmacology business Drug Antagonism Neuroscience hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 12077, p 12077 (2021) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Oxytocin (OT) and vasopressin (AVP) are hypothalamic neuropeptides classically associated with their regulatory role in reproduction, water homeostasis, and social behaviors. Interestingly, this role has expanded in recent years and has positioned these neuropeptides as therapeutic targets for various neuropsychiatric diseases such as autism, addiction, schizophrenia, depression, and anxiety disorders. Due to the chemical-physical characteristics of these neuropeptides including short half-life, poor blood-brain barrier penetration, promiscuity for AVP and OT receptors (AVP-R, OT-R), novel ligands have been developed in recent decades. This review summarizes the role of OT and AVP in neuropsychiatric conditions, as well as the findings of different OT-R and AVP-R agonists and antagonists, used both at the preclinical and clinical level. Furthermore, we discuss their possible therapeutic potential for central nervous system (CNS) disorders. |
| Databáze: | OpenAIRE |
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