IgA Triggers Cell Death of Neutrophils When Primed by Inflammatory Mediators
| Autor: | Olivia Joan Adams, Valentin Djonov, Marius Lötscher, Thomas Kaufmann, Christoph Schneider, Christoph Mueller, Fritz Daudel, Stephan von Gunten, Marc Wehrli, Christian Münz, Ruslan Hlushchuk, Kayluz Frias Boligan, Daniëlle Verschoor, Peter M. Villiger, Cédric Vonarburg, Frank Seibold, Hans-Uwe Simon, Nikhil Yawalkar, Fabiola Cortinas-Elizondo, Sylvia Miescher, Christine Engelmann |
|---|---|
| Přispěvatelé: | University of Zurich, von Gunten, Stephan |
| Rok vydání: | 2020 |
| Předmět: |
Programmed cell death
Cell Survival Neutrophils p38 mitogen-activated protein kinases Primary Cell Culture Immunology Apoptosis 610 Medicine & health Disease 10263 Institute of Experimental Immunology Arthritis Rheumatoid Sepsis Mice 03 medical and health sciences 0302 clinical medicine Immune system Crohn Disease hemic and lymphatic diseases Animals Humans Immunology and Allergy Medicine Macrophage Cells Cultured PI3K/AKT/mTOR pathway 2403 Immunology business.industry Macrophages Immunoglobulins Intravenous medicine.disease Coculture Techniques Immunoglobulin A Rheumatoid arthritis 2723 Immunology and Allergy 570 Life sciences biology business 030215 immunology |
| Zdroj: | The Journal of Immunology. 205:2640-2648 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.1900883 |
| Popis: | IVIG preparations consisting of pooled IgG are increasingly used for the treatment of autoimmune diseases. IVIG is known to regulate the viability of immune cells, including neutrophils. We report that plasma-derived IgA efficiently triggers death of neutrophils primed by cytokines or TLR agonists. IgA-mediated programmed neutrophil death was PI3K-, p38 MAPK–, and JNK-dependent and evoked anti-inflammatory cytokines in macrophage cocultures. Neutrophils from patients with acute Crohn's disease, rheumatoid arthritis, or sepsis were susceptible to both IgA- and IVIG-mediated death. In contrast to IVIG, IgA did not promote cell death of quiescent neutrophils. Our findings suggest that plasma-derived IgA might provide a therapeutic option for the treatment of neutrophil-associated inflammatory disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|