Neuropeptide receptor status in human tumor cell lines
| Autor: | Thierry Petit, Richard Lawrence, Von Hoff Dd, Elzbieta Izbicka, K Davidson |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Receptors
Neuropeptide Cancer Research CD30 medicine.medical_treatment Neuropeptide Substance P Biology Radioligand Assay Paracrine signalling chemistry.chemical_compound Tumor Cells Cultured medicine Humans Pharmacology (medical) RNA Messenger RNA Neoplasm Receptor Autocrine signalling DNA Primers Pharmacology Reverse Transcriptase Polymerase Chain Reaction Oncology chemistry Cancer research Cannabinoid Cell Division Neurotensin |
| Zdroj: | Anti-Cancer Drugs. 12:133-136 |
| ISSN: | 0959-4973 |
| Popis: | Tumor types expressing a neuroendocrine phenotype secrete neuropeptides with paracrine or autocrine growth factor activity. The efficacy of these paracrine or autocrine loops depends on the expression of specific receptors on tumor cells. Once specific receptors are identified, specific neuropeptide antagonists disrupting paracrine and autocrine loops could be potential treatments in neuropeptide-secreting tumors. In the present study, 11 human tumor cell lines representing astrocytoma, lymphoma, and pancreatic, prostate, lung and colon carcinomas were examined for expression of five different neuropeptide receptors (cholecystokinin, neurotensin, vasopressin, tachykinine substance P and cannabinoid) using RT-PCR and radioligand binding. The presence of various neuropeptide receptors in different human cancer cell lines supports development of new antitumor treatments based on disruption of neuropeptide autocrine growth pathways. |
| Databáze: | OpenAIRE |
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