Improved molecular laboratory productivity by consolidation of testing on the new random-access analyzer Alinity m
| Autor: | Leana Maree, Francesca Azzato, Allison Glass, Michael J. Palm, Emily Goldstein, Patrick Braun, Heribert Knechten, Birgit Reinhardt, Martin Obermeier, Maria Krügel, Karin Pfeifer, Danijela Lucic, Alba Vilas, Laura Martínez-García, Natalia Marlowe, Gudrun Naeth, Juan Carlos Galán, Monia Pacenti, Francesco Onelia, Stéphane Chevaliez, Rory Gunson, Jens Dhein, Ajith M. Joseph, Robert Ehret |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Spectrum analyzer Consolidation (soil) diagnosis molecular assay workflow Computer science 030106 microbiology Biochemistry (medical) Clinical Biochemistry Turnaround time Manufacturing engineering 03 medical and health sciences 0302 clinical medicine Workflow lab automation Medical technology Discrete Mathematics and Combinatorics 030212 general & internal medicine R855-855.5 Productivity turnaround time Random access |
| Zdroj: | Journal of Laboratory Medicine, Vol 44, Iss 6, Pp 319-328 (2020) |
| ISSN: | 2567-9449 2567-9430 2020-0102 |
| Popis: | Objectives Automated molecular analyzers have accelerated diagnosis, allowing earlier intervention and better patient follow-up. A recently developed completely automated molecular analyzer, Alinity™ m (Abbott), offers consolidated, continuous, and random-access testing that may improve molecular laboratory workflow. Methods An international, multicenter study compared laboratory workflow metrics across various routine analyzers and Alinity m utilizing assays for human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV), hepatitis B virus (HBV), high-risk human papillomavirus (HR HPV), and sexually transmitted infection (STI) (Chlamydia trachomatis [CT]/Neisseria gonorrhoeae [NG]/Trichomonas vaginalis [TV]/Mycoplasma genitalium [MG]). Three turnaround times (TATs) were assessed: total TAT (sample arrival to result), sample onboard TAT (sample loading and test starting to result), and processing TAT (sample aspiration to result). Results Total TAT was reduced from days with routine analyzers to hours with Alinity m, independent of requested assays. Sample onboard TATs for standard workflow using routine analyzers ranged from 7 to 32.5 h compared to 2.75–6 h for Alinity m. The mean sample onboard TAT for STAT samples on Alinity m was 2.36 h (±0.19 h). Processing TATs for Alinity m were independent of the combination of assays, with 100% of results reported within 117 min. Conclusions The consolidated, continuous, random-access workflow of Alinity m reduces TATs across various assays and is expected to improve both laboratory operational efficiency and patient care. |
| Databáze: | OpenAIRE |
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