Autoantibodies against phospholipase A2 receptor in Brazilian patients with glomerular diseases
| Autor: | Sonia K. Nishida, Gianna Mastroianni Kirsztajn, Danilo Euclides Fernandes, Michelle Tiveron Passos, Cícero de Oliveira Santos Neto, Luis Eduardo Coelho Andrade |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Urology Kidney Glomerulus 030232 urology & nephrology Lupus nephritis Serum albumin Renal function 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Focal segmental glomerulosclerosis Membranous nephropathy Internal medicine medicine Humans Autoantibodies Creatinine Proteinuria biology business.industry Receptors Phospholipase A2 Glomerulonephritis medicine.disease Cross-Sectional Studies chemistry Nephrology biology.protein Kidney Diseases medicine.symptom business Brazil |
| Zdroj: | International urology and nephrology. 53(4) |
| ISSN: | 1573-2584 |
| Popis: | Recently, great progress has been made in understanding the pathogenesis of membranous nephropathy (MN) with the discovery of autoantibodies (Abs) to M-type phospholipase A2 receptor (PLA2R) in serum and in immunocomplexes deposited in glomerulus in most adult patients with primary MN. To evaluate the diagnostic performance of anti-PLA2R in Brazilian patients with MN, as well as to verify the possible association of anti-PLA2R serum levels with disease activity. 117 patients with glomerular diseases confirmed by renal biopsy underwent routinely clinical and laboratory evaluation (serum creatinine and albumin, 24-h proteinuria, urinalysis, tests for etiological investigation) and determination of serum anti-PLA2R by ELISA. 67.5% of the patients had MN, 9.4% focal segmental glomerulosclerosis, 7.7% lupus nephritis class V and 15.4%, other proteinuric glomerular diseases. The mean level of glomerular filtration rate (estimated by the CKD-EPI formula) was 79.43 mL/min (12.00–151.20 mL/min), 24 h proteinuria of 2.89 g (0–14.90 g), serum albumin of 3.79 g/dL (1.20–4.80 g/dL). Anti-PLA2R was detected in 27 patients, all with active MN, being 26 primary and 1 secondary MN. Sensitivity and specificity rates for the test were 60.5–94.7%, and positive (PPV) and negative (NPV) predictive values were 92.9 and 67.9%, respectively. Anti-PLA2R showed high specificity and PPV for the diagnosis of primary MN in Brazilian patients. There was a strong correlation between disease activity and positive anti-PLA2R. This biomarker represents an important diagnostic tool for primary MN and may contribute to the monitoring of disease activity in such patients. |
| Databáze: | OpenAIRE |
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