Uniform and blinded cause of death verification of the NELSON lung cancer screening participants
| Autor: | M A den Bakker, H.J. de Koning, C.M. van der Aalst, A.U. Yousaf-Khan, Joachim G.J.V. Aerts |
|---|---|
| Přispěvatelé: | Public Health, Pulmonary Medicine |
| Rok vydání: | 2017 |
| Předmět: |
Pulmonary and Respiratory Medicine
Cancer Research medicine.medical_specialty Lung Neoplasms Concordance Death Certificates 03 medical and health sciences 0302 clinical medicine Cohen's kappa Belgium SDG 3 - Good Health and Well-being Cause of Death Internal medicine Humans Mass Screening Medicine Registries 030212 general & internal medicine Lung cancer Early Detection of Cancer Netherlands Cause of death Lung business.industry medicine.disease Surgery medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis National Lung Screening Trial Death certificate business Lung cancer screening |
| Zdroj: | Lung Cancer, 111, 131-134. Elsevier Ireland Ltd |
| ISSN: | 1872-8332 0169-5002 |
| Popis: | Primary outcome of the Dutch-Belgian lung cancer screening trial (NELSON) is lung cancer-specific mortality. Accurate assessment of the cause of death (CoD) is crucial. As death certificates regarding the CoD can be inaccurate, a clinical expert committee (CEC) was formed to assign the CoD. In this study, the medical files of deceased lung cancer patients were reviewed and the outcomes were compared with official death certificates. The first 266 completed medical files of Dutch deceased participants who were diagnosed with lung cancer during the study or of those with lung cancer on the death certificate were selected and blinded towards arms and patients identity. The end product of the review process consisted of six possible categories which defined the graduation of certainty that lung cancer was the primary CoD. The percentage agreement and the Cohen's kappa statistics between the two CEC-memberswere calculated. The sensitivity and specificity of the official death certificates were determined. The results indicated that, the overall concordance and the Cohen's kappa between the CEC-memberswere 86.1% and 0.57(0.45-0.69, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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