Frequent Occurrence of c-Ki-ras Gene Mutations in Well Differentiated Endometrial Adenocarcinoma Showing Infiltrative Local Growth with Fibrosing Stromal Response
| Autor: | Ryuichiro Tsunematsu, Kazuo Ohmi, T Sonoda, T Yamada, Jiko K, Hirohashi S, Hitoshi Tsuda, Yajima M, Kenjiro Tanemura |
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| Rok vydání: | 1995 |
| Předmět: |
Pathology
medicine.medical_specialty Stromal cell medicine.medical_treatment Molecular Sequence Data Adenocarcinoma Gene mutation Biology Endometrium Pathology and Forensic Medicine Infiltrative Growth Pattern medicine Humans Point Mutation Neoplasm Invasiveness Neoplasm Staging Retrospective Studies Hysterectomy Base Sequence Obstetrics and Gynecology Hyperplasia medicine.disease Endometrial Neoplasms Endometrial hyperplasia Survival Rate Genes ras medicine.anatomical_structure Endometrial Hyperplasia Cancer research Female |
| Zdroj: | International Journal of Gynecological Pathology. 14:255-259 |
| ISSN: | 0277-1691 |
| DOI: | 10.1097/00004347-199507000-00010 |
| Popis: | Summary: The frequency of c-Ki-ras mutation was examined by polymerase chain reaction (single-strand conformation polymorphism and direct sequencing analysis) and its association with histological parameters was analyzed in 110 endometrial adenocarcinoma hysterectomy specimens. The c-Ki-ras mutation was detected in 24 cases (22%). It occurred irrespective of tumor size, stage or histological grade, and was more frequent in tumors associated with endometrial hyperplasia (11 of 20, 55%) than in those without (10 of 73, 14%) In addition, the frequency of the mutation was significantly higher in tumors showing an infiltrative growth pattern accompanied by a stromal response consisting of edematous fibrous tissue (19 of 58, 33%), than in those which revealed an expansive growth pattern without such a stromal reaction (five of 52, 10%). Even among tumors showing the infiltrative growth pattern, the frequency of c-Ki-ras mutation was especially high (48%) in grade I cases in comparison with grade II or III cases (20% and 19%). Mutational activation of the c-Ki-ras gene may act at two points in the developmental pathway of endometrial adenocarcinoma by enhancing evolution of hyperplasia to adenocarcinoma, and by producing an infiltrative growth with a fibrosing stromal response. |
| Databáze: | OpenAIRE |
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