Direct Visualization of the Perforant Pathway in the Human Brain with Ex Vivo Diffusion Tensor Imaging
| Autor: | Sita Kakunoori, Bruce Fischl, Jean C. Augustinack, Lilla Zöllei, Kristen E. Huber, Karl G. Helmer |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
hippocampus
Hippocampus lcsh:RC321-571 Temporal lobe White matter 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine medicine dentate gyrus lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Biological Psychiatry Original Research 030304 developmental biology Physics 0303 health sciences medicine.diagnostic_test Perforant Pathway entorhinal cortex resolution Magnetic resonance imaging Human brain Psychiatry and Mental health Neuropsychology and Physiological Psychology medicine.anatomical_structure Neurology Cytoarchitecture presubiculum subiculum Neuroscience 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Frontiers in Human Neuroscience Frontiers in Human Neuroscience, Vol 4 (2010) |
| ISSN: | 1662-5161 |
| DOI: | 10.3389/fnhum.2010.00042 |
| Popis: | Ex vivo magnetic resonance imaging yields high resolution images that reveal detailed cerebral anatomy and explicit cytoarchitecture in the cerebral cortex, subcortical structures, and white matter in the human brain. Our data illustrate neuroanatomical correlates of limbic circuitry with high resolution images at high field. In this report, we have studied ex vivo medial temporal lobe samples in high resolution structural MRI and high resolution diffusion MRI. Structural and diffusion MRIs were registered to each other and to histological sections stained for myelin for validation of the perforant pathway. We demonstrate probability maps and fiber tracking from diffusion tensor data that allows the direct visualization of the perforant pathway. Although it is not possible to validate the DTI data with invasive measures, results described here provide an additional line of evidence of the perforant pathway trajectory in the human brain and that the perforant pathway may cross the hippocampal sulcus. |
| Databáze: | OpenAIRE |
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