Experimental Modelling of Chronic Obstructive Pulmonary Disease
| Autor: | T. N. Preobrazhenskaya, I. V. Dvorakovskaya, I. S. Platonova, L. N. Danilov, Elena Lebedeva, Olga Titova, N. A. Kuzubova, M. Ya. Kozlova |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Pathology medicine.medical_specialty CD3 Complex Nitrogen Dioxide Inflammation Antigen-Antibody Complex Lung injury General Biochemistry Genetics and Molecular Biology Pulmonary Disease Chronic Obstructive Immune system Transforming Growth Factor beta Metaplasia Parenchyma Animals Medicine Lymphocytes Rats Wistar Lung Pathological Tumor Necrosis Factor-alpha business.industry General Medicine respiratory system Hyperplasia medicine.disease Rats Disease Models Animal Pulmonary Emphysema Chronic Disease Immunology Tumor necrosis factor alpha Goblet Cells medicine.symptom business |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 152:659-663 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | A method for experimental reproduction of stages of chronic obstructive pulmonary disease formation (from acute inflammation to bronchopulmonary tissue restructuring characteristic of this disease) is presented. Lung injury and inflammation were induced by nitrogen dioxide. Hyperplasia and hypersecretion of goblet cells, squamous cell metaplasia of the ciliary epithelium, emphysema, and focal fibrosis served as the morphological substrate for the formation of bronchial obstruction. The adequacy of the model is confirmed by signs characteristic of chronic obstructive pulmonary disease: hyperexpression of CD3 lymphocytes in the bronchial wall and parenchyma, manifold increased production of TNFα and TGFβ, high concentrations of circulating pathogenic immune complexes. Persistence of the structural and functional shifts throughout 6 months after exposure to nitrogen dioxide indicated a chronic course of the resultant pathological process. |
| Databáze: | OpenAIRE |
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