The neuronal and endothelium-dependent relaxing responses of human corpus cavernosum under physiological oxygen tension last longer than previously expected
| Autor: | Yasuo Kawanishi, Kazunori Kimura, Susumu Kagawa |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Vasodilator Agents Urology chemistry.chemical_element Isometric exercise In Vitro Techniques Nitric Oxide Oxygen Nitric oxide Norepinephrine chemistry.chemical_compound Internal medicine Humans Vasoconstrictor Agents Medicine Aged Relaxation (psychology) business.industry Human penis Penile Erection Middle Aged Acetylcholine Electric Stimulation Oxygen tension Endocrinology medicine.anatomical_structure chemistry Anesthesia Potassium Endothelium Vascular business Penis medicine.drug |
| Zdroj: | International Journal of Urology. 11:321-325 |
| ISSN: | 1442-2042 0919-8172 |
| DOI: | 10.1111/j.1442-2042.2004.00801.x |
| Popis: | Background: Intracavernosal oxygen tension varies greatly in the process of erection. Blood extracted from the human penis demonstrates an increase from approximately 30 mmHg Po2 in the flaccid state to 100 mmHg in the erect state of the penis. In the present study, using these levels as a guide, we investigate how the NO-dependent relaxation of human corpus cavernosum changed under physiological oxygen tensions ranging from approximately 30 to 100 mmHg. Methods: Human penile tissue specimens were obtained at penile surgery with informed consent from the patients. The preparations were mounted in Krebs solution in an organ bath and the isometric tension was recorded. Krebs solutions of various oxygen tensions were prepared by bubbling 5% CO2 in N2 and O2. The NO-dependent relaxation caused by electrical field stimulation (EFS) and acetylcholine (ACh) was studied, and the amplitude and duration of relaxation evaluated. Results: The amplitude of relaxation induced by EFS was significantly decreased under physiological oxygen tension conditions (P |
| Databáze: | OpenAIRE |
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