Characteristics, interventions, and longer term outcomes of COVID-19 ICU patients in Denmark—A nationwide, observational study
| Autor: | Niels Erik Ribergaard, Margit Smitt, Helle Bundgaard, Helle B.S. Pedersen, Lynge Kirkegaard, Henrik Pedersen, Thomas Mohr, Bodil Steen Rasmussen, Vibeke Lind Jørgensen, Anne Craveiro Brøchner, Jens Michelsen, Ulrick Skipper Espelund, Steffen Christensen, Lars Peter Kloster Andersen, Ronni Plovsing, Susanne Iversen, Robert Winding, Michael Ibsen, Birgitte V. Christensen, David Levarett Buck, Lone Musaeus Poulsen, Jens-Ulrik Stæhr Jensen, Anne Mannering, Hanna Siegel, Marie Helleberg, Jacob Madsen, Ricardo Sanchez Garcia, Anders Perner, Christoffer Sølling, Nicolai Haase |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Critical Care medicine.medical_treatment Denmark Population Vital signs Comorbidity comorbidities law.invention Cohort Studies Concurrent Review law Risk Factors Intensive care medicine Humans Renal replacement therapy Hospital Mortality education Aged Demography intensive care education.field_of_study business.industry Vital Signs SARS-CoV-2 COVID-19 General Medicine Length of Stay Middle Aged medicine.disease Intensive care unit mortality Anesthesiology and Pain Medicine Treatment Outcome Emergency medicine Cohort Female business Cohort study |
| Zdroj: | Haase, N, Plovsing, R, Christensen, S, Poulsen, L M, Brøchner, A C, Rasmussen, B S, Helleberg, M, Jensen, J U S, Andersen, L P K, Siegel, H, Ibsen, M, Jørgensen, V, Winding, R, Iversen, S, Pedersen, H P, Madsen, J, Sølling, C, Garcia, R S, Michelsen, J, Mohr, T, Mannering, A, Espelund, U S, Bundgaard, H, Kirkegaard, L, Smitt, M, Buck, D L, Ribergaard, N E, Pedersen, H B S, Christensen, B V & Perner, A 2021, ' Characteristics, interventions, and longer term outcomes of COVID-19 ICU patients in Denmark—A nationwide, observational study ', Acta Anaesthesiologica Scandinavica, vol. 65, no. 1, pp. 68-75 . https://doi.org/10.1111/aas.13701 Haase, N, Plovsing, R, Christensen, S, Poulsen, L M, Brøchner, A C, Rasmussen, B S, Helleberg, M, Jensen, J U S, Andersen, L P K, Siegel, H, Ibsen, M, Jørgensen, V, Winding, R, Iversen, S, Pedersen, H P, Madsen, J, Sølling, C, Garcia, R S, Michelsen, J, Mohr, T, Mannering, A, Espelund, U S, Bundgaard, H, Kirkegaard, L, Smitt, M, Buck, D L, Ribergaard, N, Pedersen, H S, Christensen, B V & Perner, A 2021, ' Characteristics, interventions, and longer term outcomes of COVID-19 ICU patients in Denmark—A nationwide, observational study ', Acta Anaesthesiologica Scandinavica, vol. 65, no. 1, pp. 68-75 . https://doi.org/10.1111/aas.13701 Acta Anaesthesiologica Scandinavica Haase, N, Plovsing, R, Christensen, S, Poulsen, L M, Brøchner, A C, Rasmussen, B S, Helleberg, M, Jensen, J U S, Andersen, L P K, Siegel, H, Ibsen, M, Jørgensen, V, Winding, R, Iversen, S, Pedersen, H P, Madsen, J, Sølling, C, Garcia, R S, Michelsen, J, Mohr, T, Mannering, A, Espelund, U S, Bundgaard, H, Kirkegaard, L, Smitt, M, Buck, D L, Ribergaard, N-E, Pedersen, H S, Christensen, B V & Perner, A 2021, ' Characteristics, interventions and longer-term outcomes of COVID-19 ICU patients in Denmark-a nationwide, observational study ', Acta Anaesthesiologica Scandinavica, vol. 65, no. 1, pp. 68-75 . https://doi.org/10.1111/aas.13701 |
| Popis: | BackgroundMost data on intensive care unit (ICU) patients with COVID-19 originate in selected populations from stressed healthcare systems with shorter term follow-up. We present characteristics, interventions and longer term outcomes of the entire, unselected cohort of all ICU patients with COVID-19 in Denmark where the ICU capacity was not exceeded.MethodsWe identified all patients with SARS-CoV-2 admitted to any Danish ICU from 10 March to 19 May 2020 and registered demographics, chronic comorbidities, use of organ support, length of stay, and vital status from patient files. Risk factors for death were analyzed using adjusted Cox regression analysis.ResultsThere were 323 ICU patients with confirmed COVID-19. Median age was 68 years, 74% were men, 50% had hypertension, 21% diabetes, and 20% chronic pulmonary disease; 29% had no chronic comorbidity. Invasive mechanical ventilation was used in 82%, vasopressors in 83%, renal replacement therapy in 26%, and extra corporeal membrane oxygenation in 8%. ICU stay was median 13 days (IQR 6-22) and hospital stay 19 days (11-30). Median follow-up was 79 days. At end of follow-up, 118 had died (37%), 15 (4%) were still in hospital hereof 4 in ICU as of 16 June 2020. Risk factors for mortality included male gender, age, chronic pulmonary disease, active cancer, and number of co-morbidities.ConclusionsIn this nationwide, population-based cohort of ICU patients with COVID-19, longer term survival was high despite high age and substantial use of organ support. Male gender, age, and chronic co-morbidities, in particular chronic pulmonary disease, were associated with increased risk of death. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|