Circulating microRNAs as potentially new diagnostic biomarkers of idiopathic sudden sensorineural hearing loss

Autor:	Dong Jun Park, Jeongeun Park, Il Hwan Park, Sunyoung Park, Jin Sil Choi, Hyeyoung Lee, Young Joon Seo, Su Hoon Lee, Kyu Rin Hwang, Ha Sun Mok
Rok vydání:	2020
Předmět:	Hearing Loss Sensorineural Early detection Sensitivity and Specificity 03 medical and health sciences 0302 clinical medicine microRNA otorhinolaryngologic diseases medicine Humans Diagnostic biomarker Inner ear Circulating MicroRNA 030223 otorhinolaryngology Cell damage Hearing ability Reverse Transcriptase Polymerase Chain Reaction business.industry fungi food and beverages General Medicine Hearing Loss Sudden medicine.disease Treatment Outcome medicine.anatomical_structure ROC Curve Otorhinolaryngology Case-Control Studies Ear Inner 030220 oncology & carcinogenesis Sudden sensorineural hearing loss Immunology Audiometry Pure-Tone sense organs business Biomarkers
Zdroj:	Acta Oto-Laryngologica. 140:1013-1020
ISSN:	1651-2251 0001-6489
Popis:	Early detection of inner ear cell damage can reduce the chances of permanent damage to hearing ability. However, current inner ear cell damage detection methods can detect damage only after the patient has lost hearing ability. MicroRNA expression levels in circulating systems are affected in diseases or conditions arising from the distant lesions. Therefore, detection of circulating microRNA expression levels could be one of the best ways to obtain information on inaccessible lesion sites.This study aims to establish a method for monitoring idiopathic sudden sensorineural hearing loss (ISSNHL) by analyzing circulating microRNA expression levels. 21 ISSNHL patients and 24 healthy controls were enrolled.Real-time quantitative polymerase chain reaction was performed for detecting expression levels of circulating microRNAs.Among eight circulating microRNAs, expression levels of five circulating microRNAs significantly differed between ISSNHL patients and healthy controls. circulating microRNA expression levels correlates with treatment outcomes and hearing ability.Using methods combining the evaluation of miR-183, miR-210, miR-18b, and miR-23a cut-off values identified in ISSNHL patients and healthy controls during receiver operating characteristic curve analysis, sensitivity and specificity of 80.95% (17/21) and 87.50% (21/24) were obtained, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410e3dd13c6cd421476bf7c93e55fe28 https://doi.org/10.1080/00016489.2020.1810859 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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