Muscarinic cholinoceptors in the ventromedial hypothalamic nucleus facilitate tail heat loss during physical exercise
| Autor: | Samuel Penna Wanner, Umeko Marubayashi, Juliana B. Guimarães, Nilo R. V. Lima, Cândido C. Coimbra, Luiz Oswaldo Carneiro Rodrigues |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Tail medicine.medical_specialty Pentobarbital Sodium Physical Exertion chemistry.chemical_element Physical exercise Biosensing Techniques Muscarinic Antagonists Methylatropine Running chemistry.chemical_compound Internal medicine Muscarinic acetylcholine receptor medicine Animals Atropine Derivatives Rats Wistar Skin Chemistry General Neuroscience Thermoregulation Receptors Muscarinic Electrodes Implanted Rats Endocrinology Hypothalamus Regional Blood Flow Ventromedial Hypothalamic Nucleus Muscle Fatigue Acetylcholine medicine.drug Body Temperature Regulation |
| Zdroj: | Brain research bulletin. 73(1-3) |
| ISSN: | 0361-9230 |
| Popis: | The aim of this study was to evaluate the participation of ventromedial hypothalamic nucleus (VMH) muscarinic cholinoceptors in heat balance and central fatigue during treadmill exercise (24 m min(-1), 5% inclination). The animals were anesthetized with pentobarbital sodium (50 mg/kg body weight i.p.) and fitted with bilateral cannulae into the VMH 1 week prior to the experiments. Tail skin (T(tail)) and core body temperatures (T(b)) were measured after the injection of 0.2 microL of 5 x 10(-9) mol methylatropine (Matr) or 0.15 M NaCl solution (Sal) into the hypothalamus. Methylatropine injection into the VMH greatly increased heat storage rate (HSR) measured until fatigue (19.7+/-4.6 cal min(-1) Matr versus 9.7+/-3.3 cal min(-1) Sal; P |
| Databáze: | OpenAIRE |
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