Study of human red blood cell geometry using digital holographic microscopy and mathematical models for cell shape in biomedical imaging
| Autor: | Bhabhor, Gaurav D., Patel, Chetna, Anand, Arun, Lad, Kirit N. |
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| Rok vydání: | 2023 |
| Předmět: | |
| DOI: | 10.48550/arxiv.2301.12879 |
| Popis: | Shape of red blood cells is a critical factor in their characterization, and from this point of view, their geometrical modeling becomes essential. The suitability of three frequently used analytical models for modeling the geometrical shape and size of the human red blood cells, in light scattering experiments and, computer simulation studies of biophysical properties of the cell membrane, is assessed. The 2D and 3D thickness profiles of healthy RBCs have been generated from the parametric equations of these models and compared to the experimentally obtained thickness profiles using digital holographic microscopy. The study reveals that the models considering the biomechanical properties of cell membranes provide a better description of the biconcave discoid shape of the RBCs. Statistical distributions and descriptive statistics of the geometrical parameters of the RBCs suggest that the evaluation of these parameters alone is insufficient for identifying cells of specific shape, which is crucial for diagnosis using biomedical imaging techniques. Comment: 23 pages, 14 figures |
| Databáze: | OpenAIRE |
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