Curcumin improves liver damage in male mice exposed to nicotine
| Autor: | Sabah Mohamadian, Shiva Roshankhah, Mohammad Reza Salahshoor, Cyrus Jalili, Seyran Kakabaraei |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Antioxidant mice medicine.medical_treatment lcsh:Medicine Pharmacology liver Nitric oxide Nicotine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Blood serum medicine curcumin Saline lcsh:R 030104 developmental biology medicine.anatomical_structure Complementary and alternative medicine chemistry 030220 oncology & carcinogenesis Hepatocyte Curcumin Alkaline phosphatase Original Article damage medicine.drug nicotine |
| Zdroj: | Journal of Traditional and Complementary Medicine, Vol 6, Iss 2, Pp 176-183 (2016) Journal of Traditional and Complementary Medicine |
| ISSN: | 2225-4110 |
| Popis: | The color of turmeric (薑黃 jiāng huáng) is because of a substance called curcumin. It has different pharmacological effects, such as antioxidant and anti-inflammatory properties. Nicotine is a major pharmacologically active substance in cigarette smoke. It is mainly metabolized in the liver and causes devastating effects. This study was designed to evaluate the protective role of curcumin against nicotine on the liver in mice. Forty-eight mice were equally divided into eight groups; control (normal saline), nicotine (2.5 mg/kg), curcumin (10, 30, and 60 mg/kg) and curcumin plus nicotine-treated groups. Curcumin, nicotine, and curcumin plus nicotine (once a day) were intraperitoneally injected for 4 weeks. The liver weight and histology, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and serum nitric oxide levels have been studied. The results indicated that nicotine administration significantly decreased liver weight and increased the mean diameter of hepatocyte, central hepatic vein, liver enzymes level, and blood serum nitric oxide level compared with the saline group (p Graphical abstract |
| Databáze: | OpenAIRE |
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