Serum levels of thyroid hormones and thyroid stimulating hormone in patients with biliogenic and hyperlipidaemic acute pancreatitis: Difference and value in predicting disease severity

Autor: Jianyu Hao, Ning Yang, Guang Wang, Dong-Lei Zhang
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
endocrine system diseases
severity
Thyrotropin
Thyroid Function Tests
Biochemistry
Severity of Illness Index
chemistry.chemical_compound
0302 clinical medicine
Risk Factors
Hyperlipidemia
Aged
80 and over
Triiodothyronine
medicine.diagnostic_test
General Medicine
Middle Aged
Prognosis
Acute Disease
Acute pancreatitis
Female
biliogenic acute pancreatitis
hormones
hormone substitutes
and hormone antagonists
Adult
medicine.medical_specialty
endocrine system
acute pancreatitis
030209 endocrinology & metabolism
Hyperlipidemias
Thyroid function tests
03 medical and health sciences
Thyroid-stimulating hormone
Internal medicine
Severity of illness
medicine
Humans
Aged
Retrospective Studies
thyroid hormones
Triglyceride
business.industry
Biochemistry (medical)
Research Reports
Cell Biology
thyroid stimulating hormone
medicine.disease
Thyroxine
030104 developmental biology
Endocrinology
chemistry
Pancreatitis
Bile Ducts
Hyperlipidaemic acute pancreatitis
business
Biomarkers
Zdroj: The Journal of International Medical Research
ISSN: 1473-2300
0300-0605
Popis: ObjectivesTo compare retrospectively serum levels of thyroid hormones (THs) and thyroid stimulating hormone (TSH) between patients with biliogenic acute pancreatitis (BAP) and those with hyperlipidaemic acute pancreatitis (HLAP), in order to assess their value for predicting the severity of acute pancreatitis (AP).MethodsPatients with AP were divided into BAP and HLAP groups, then further divided into either a mild AP (MAP) group or a moderately severe AP (MSAP) group. Routine blood parameters were measured. Free tri-iodothyronine (FT3), free thyroxine (FT4) and TSH levels were measured.ResultsSeventy-six patients with AP were enrolled in the study. FT3 and TSH levels were significantly higher in patients with MAP than in patients with MSAP. FT4 and TSH levels were significantly lower in the HLAP group than in the BAP group. TSH levels in both MAP and MSAP patients were significantly lower in the HLAP group than in the BAP group. TSH was inversely correlated with triglyceride levels in patients with HLAP. FT3 was a risk factor for MSAP in patients with AP and also demonstrated moderate accuracy in predicting AP severity.ConclusionsTHs and TSH decrease with the severity of AP, especially in patients with HLAP. FT3 may be a useful biomarker for the early assessment of the severity of AP.
Databáze: OpenAIRE
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