High toll-like receptor (TLR) 9 expression is associated with better prognosis in surgically treated pancreatic cancer patients
| Autor: | Heikki Huhta, Kirsi-Maria Haapasaari, Joni Leppänen, Joonas H. Kauppila, Tuomo J. Karttunen, Olli Helminen, Joel Isohookana, Petri Lehenkari, Juha Saarnio |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male Pathology medicine.medical_specialty Kaplan-Meier Estimate Pathology and Forensic Medicine Pathogenesis 03 medical and health sciences 0302 clinical medicine Pancreatic cancer medicine Biomarkers Tumor Humans Molecular Biology Aged Proportional Hazards Models business.industry TLR9 Cell Biology General Medicine Middle Aged medicine.disease Prognosis Immunohistochemistry Pancreatic Neoplasms TLR2 030104 developmental biology 030220 oncology & carcinogenesis Toll-Like Receptor 9 Cancer research TLR4 Tumor necrosis factor alpha CA19-9 Female business Carcinoma Pancreatic Ductal |
| Zdroj: | Virchows Archiv : an international journal of pathology. 470(4) |
| ISSN: | 1432-2307 |
| Popis: | Pancreatic cancer remains one of the deadliest malignancies in the world. Inflammatory response and tumor environment are thought to play a major role in its pathogenesis. Knowledge on TLR expression and impact on patient survival in pancreatic cancer is limited. The study's aim was to clarify the role of different TLRs in pancreatic cancer. TLR2, TLR4, and TLR9 expression was investigated in 65 surgically resected pancreatic ductal adenocarcinoma specimens by immunohistochemistry. The association between TLR expression, clinical parameters, and local inflammatory response to the tumor was assessed using chi-square test. Relation between patient survival and TLR expression was calculated with multivariable Cox regression, adjusted for age, sex, and tumor stage. We found TLR2, TLR4, and TLR9 to be expressed in pancreatic cancer. There was no association between TLR expression and tumor stage, tumor size, lymph node metastasis, or tumor necrosis. Contrary to our initial hypothesis, high cytoplasmic TLR9 expression was associated with longer patient survival, and multivariate analysis identified low TLR9 expression as an independent risk factor for cancer-specific death (HR 3.090, 95% CI 1.673-5.706). The results suggest that high TLR9 expression in pancreatic ductal adenocarcinoma indicates improved prognosis. The prognostic effect of TLR9 might be associated with bacterial exposure, but this needs further evidence. |
| Databáze: | OpenAIRE |
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