Vanadium(V) complexes with hydrazides and their spectroscopic and biological properties

Autor: Mohammad Mahroof-Tahir, Zara Shaikh, Sadaf Sultan, Uzma Ashiq, Mehreen Lateef, Lubna Iqbal, Bushra Shamshad, Rifat Ara Jamal
Rok vydání: 2017
Předmět:
Xanthine Oxidase
Vanadium(V)
Magnetic Resonance Spectroscopy
Vanadium Compounds
Spectrophotometry
Infrared
Radical scavenging
Lipoxygenase
Drug Evaluation
Preclinical
Substituent
Vanadium
chemistry.chemical_element
Ligands
Nitric Oxide
010402 general chemistry
Hydrazide
01 natural sciences
Medicinal chemistry
Antioxidants
General Biochemistry
Genetics and Molecular Biology
Biomaterials
chemistry.chemical_compound
Picrates
Coordination Complexes
Octahedral molecular geometry
Organic chemistry
Lipoxygenase Inhibitors
Xanthine oxidase
Enzyme Inhibitors
Superoxide Dismutase
010405 organic chemistry
Superoxide
Biphenyl Compounds
Metals and Alloys
Free Radical Scavengers
Nuclear magnetic resonance spectroscopy
0104 chemical sciences
Biphenyl compound
Hydrazines
chemistry
Enzyme
General Agricultural and Biological Sciences
Zdroj: BioMetals. 30:873-891
ISSN: 1572-8773
0966-0844
DOI: 10.1007/s10534-017-0054-6
Popis: The present study explores the synthesis and inhibitory potential of vanadium(V) complexes of hydrazides (1c-12c) against oxidative enzymes including xanthine oxidase and lipoxygenase (LOX). In addition, non-enzymatic radical scavenging activities of these complexes were also determined. On the basis of spectral, elemental and physical data, synthesized vanadium(V) complexes are tentatively assigned to have an octahedral geometry with two hydrazide ligands and two oxo groups forming a negatively charged sphere complex with ammonium as counter ion. This is further verified by the conductivity studies of the complexes. Results show that hydrazide ligands (1-12) and their respective vanadium(V) complexes (1c-12c) posses scavenging and inhibition potential against DPPH and LOX, respectively. However, contrary to that uncoordinated ligands showed no activity against nitric oxide, superoxide and xanthine oxidase whereas their complexes showed varying degree of activity. These studies indicate that geometry of complex, nature and position of substituent groups play a vital role in scavenging and inhibition potential of these compounds. 1 2017, Springer Science+Business Media, LLC. Acknowledgements S. Sultan is thankful to the Higher Education Commission for Indigenous Scholarship No. 112-34080-2PS1-155 under PhD Fellowships for 5000 scholars, HEC (Phase-II). Authors are thankful to the Higher Education Commission of Pakistan for financial support ('The National Research Grants Program for Universities', Grant No. 1862/R&D/10). Scopus
Databáze: OpenAIRE
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