Neutrophil-lymphocyte ratio as a predictor of delirium in older internal medicine patients: a prospective cohort study
| Autor: | Xuchao Peng, Yanli Zhao, Chenkai Wu, Xiaoyu Shu, Dongmei Xie, Taiping Lin, Jirong Yue, Peng Lei, Langli Gao |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
China
medicine.medical_specialty Neutrophils Lymphocyte Youden's J statistic Logistic regression behavioral disciplines and activities 03 medical and health sciences 0302 clinical medicine Internal medicine mental disorders Internal Medicine Humans Medicine Lymphocytes Prospective Studies 030212 general & internal medicine Risk factor Prospective cohort study Neutrophil-lymphocyte ratio Aged Retrospective Studies business.industry Incidence (epidemiology) fungi RC952-954.6 Delirium medicine.anatomical_structure Quartile Geriatrics Older people Geriatrics and Gerontology medicine.symptom business 030217 neurology & neurosurgery Research Article |
| Zdroj: | BMC Geriatrics BMC Geriatrics, Vol 21, Iss 1, Pp 1-9 (2021) |
| ISSN: | 1471-2318 |
| DOI: | 10.1186/s12877-021-02284-w |
| Popis: | Backgrounds Delirium is a common neuropsychiatric syndrome in older hospitalized patients. Previous studies have suggested that inflammation and oxidative stress contribute to the pathophysiology of delirium. However, it remains unclear whether neutrophil-lymphocyte ratio (NLR), an indicator of systematic inflammation, is associated with delirium. This study aimed to investigate the value of NLR as an independent risk factor for delirium among older hospitalized patients. Methods We conducted a prospective study of 740 hospitalized patients aged ≥ 70 years in the geriatric ward of West China Hospital of Sichuan University. Neutrophil and lymphocyte counts were collected within 24 h after hospital admission. Delirium was assessed on admission and every 48 h thereafter. We used the receiver operating characteristic analysis to assess the ability of the NLR for predicting delirium. The optimal cut-point value of the NLR was determined based on the highest Youden index (sensitivity + specificity − 1). Patients were categorized according to the cut-point value and quartiles of NLR, respectively. We then used logistic regression to identify the unadjusted and adjusted associations between NLR as a categorical variable and delirium. Results The optimal cut-point value of NLR for predicting delirium was 3.626 (sensitivity: 75.2 %; specificity: 63.4 %; Youden index: 0.386). The incidence of delirium was significantly higher in patients with NLR > 3.626 than NLR ≤ 3.626 (24.5 % vs. 5.8 %; P P P Conclusions NLR is a simple and practical marker that can predict the development of delirium in older internal medicine patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink