The original haemorrhagic fever: yellow fever
| Autor: | Marcel E. Conrad, Dan Crozier, James Crosbie, Boris E. Reisberg, Lewis H. Dennis |
|---|---|
| Rok vydání: | 1969 |
| Předmět: |
Globulin
Fibrinogen Virus Body Temperature Yellow Fever medicine Animals Platelet Prothrombin time biology medicine.diagnostic_test business.industry Heparin Yellow fever Hematology Haplorhini Blood Coagulation Disorders medicine.disease Blood Coagulation Factors Coagulation Liver Immunology biology.protein Prothrombin Time Serum Globulins business medicine.drug |
| Zdroj: | British journal of haematology. 17(5) |
| ISSN: | 0007-1048 |
| Popis: | Monkeys infected with the Asibi strain of yellow fever virus developed multiple coagulation abnormalities 3-4 days after viral inoculation. These coagulation abnormalities occurred almost simultaneously with the development of fever, clinical illness and pathologic changes in the liver. The haemorrhagic manifestation of yellow fever and the rapid development of multiple coagulation abnormalities cannot be explained solely by impaired production of coagulation proteins and suggested that there was accelerated intravascular coagulation. Heparin therapy in one group of infected animals decreased the severity of coagulation abnormalities but did not prolong the life of these animals. |
| Databáze: | OpenAIRE |
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