Parental morphine exposure affects repetitive grooming actions and marble burying behavior in the offspring: Potential relevance for obsessive-compulsive like behavior
| Autor: | Solmaz Khalifeh, Mitra-Sadat Sadat-Shirazi, Setareh Nouri Zadeh-Tehrani, Mahsa Ale-Ebrahim, Saba Sabzevari, Mohammad-Reza Zarrindast, Ghorbangol Ashabi, Kiyana Rohbani |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Obsessive-Compulsive Disorder medicine.medical_specialty Offspring media_common.quotation_subject Nucleus accumbens Nucleus Accumbens Marble burying 03 medical and health sciences 0302 clinical medicine Pregnancy Internal medicine Animals Medicine Rats Wistar Maternal-Fetal Exchange media_common Pharmacology Behavior Animal Morphine Receptors Dopamine D2 business.industry Brain-Derived Neurotrophic Factor Addiction Grooming Analgesics Opioid Disease Models Animal Drug-naïve 030104 developmental biology Endocrinology Opioid Dopamine receptor Prenatal Exposure Delayed Effects Compulsive Behavior Anxiety Female medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | European Journal of Pharmacology. 865:172757 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/j.ejphar.2019.172757 |
| Popis: | Family, adoption and twin studies have highlighted the significant role of heritable influences on individual differences in opioid addiction. Meanwhile, obsessive-compulsive disorder (OCD) is a disorder wherein the individual experiences recurring thoughts that cause irrational fears and anxiety. In the present study, adult male and female rats received morphine solution for 21 days and were drug-free for 10 days. Offspring were used in 4 distinct groups; (1) paternal morphine-exposed, (2) maternal morphine-exposed, (3) maternal and paternal morphine-exposed, and (4) drug-naive subjects. We assessed the grooming behavior and marble burying test as an indicator of obsessive-compulsive behavior. To clarify the mechanisms underlying these changes, the mRNA level of BDNF, the phosphorylation level of CREB and the protein level of D2 dopamine receptor (DR) were evaluated in the nucleus accumbens (NAc). The grooming behavior in male offspring with one or two morphine-abstinent parent(s) increased compared with the offspring of drug naive rats. In addition, the offspring of morphine-exposed parents buried more marbles when compared with the offspring of drug-naive parents. Also, the BDNF mRNA was down-regulated in the NAC. However, the levels of phospho-CREB and D2 DR were elevated. Previous studies indicated that exposure to morphine in adulthood enhances the risk of psychiatric disorders in offspring. OCD is one the comorbid disorders with addiction and increases the risk of substance abuse disorder in patients. In this survey, we found that morphine exposure in parents before gestation can encourage obsessive-compulsive behavior in offspring. |
| Databáze: | OpenAIRE |
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