Postmarketing surveillance study of permethrin creme rinse
| Autor: | Elizabeth Andrews, M C Joseph, M W Schultz, M J Magenheim, P A Doi, Hugh H. Tilson |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Insecticides Veterinary medicine medicine.medical_specialty Adolescent Pediculosis Postmarketing surveillance Nonprescription Drugs Drug Hypersensitivity Internal medicine Pyrethrins parasitic diseases Epidemiology Pharmacovigilance Product Surveillance Postmarketing medicine Adverse Drug Reaction Reporting Systems Humans Child Adverse effect Permethrin Scalp business.industry Public Health Environmental and Occupational Health Lice Infestations medicine.disease United States Clinical trial Female Observational study business Hexachlorocyclohexane Research Article medicine.drug |
| Zdroj: | American Journal of Public Health. 82:857-861 |
| ISSN: | 1541-0048 0090-0036 |
| DOI: | 10.2105/ajph.82.6.857 |
| Popis: | BACKGROUND. An observational, epidemiological study was undertaken to evaluate the safety of permethrin 1% creme rinse (Nix) for treatment of head lice infestations. METHODS. Thirty-seven local public health departments enrolled a total of 38,160 patients for 47,578 treatments with permethrin or other pediculicides from September 1, 1986, through January 31, 1988. Follow-up safety information was collected between 7 and 14 days following treatment via return visit or telephone contact. RESULTS. One hundred three adverse events were reported among 41,955 evaluable treatments. The rates of reported adverse events were 2.2 per 1000 treatments among permethrin treatments, 3.4 per 1000 treatments among lindane treatments, and 1.5 per 1000 treatments among other over-the-counter treatments. No serious, unexpected adverse events were detected in the 18,950 patients treated with permethrin. CONCLUSIONS. This study confirmed the safety profile of permethrin in conditions of general use, as seen in clinical trials. Postmarketing safety monitoring in public health departments of drugs used to treat public health conditions was shown to be feasible. |
| Databáze: | OpenAIRE |
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