Pathogen-driven gastrointestinal cancers: Time for a change in treatment paradigm?
| Autor: | Assem Duisembekova, Assel Bulenova, Bauyrzhan Aituov, Ken Alibek |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Cancer Research
Colorectal cancer Epidemiology Cellular differentiation Cytomegalovirus Review medicine.disease_cause lcsh:RC254-282 lcsh:Infectious and parasitic diseases John Cunningham virus medicine Epstein-Barr virus Streptococcus bovis lcsh:RC109-216 Gene biology Helicobacter pylori business.industry Hepatitis C virus Cancer medicine.disease biology.organism_classification lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Epstein–Barr virus Infectious Diseases Oncology Helminthes Immunology Liver cancer business Carcinogenesis Gastric cancer |
| Zdroj: | Infectious Agents and Cancer, Vol 7, Iss 1, p 18 (2012) Infectious Agents and Cancer |
| ISSN: | 1750-9378 |
| Popis: | The regulation of cancerous tumor development is converged upon by multiple pathways and factors. Besides environmental factors, gastrointestinal (GI) tract cancer can be caused by chronic inflammation, which is generally induced by bacteria, viruses, and parasites. The role of these inducers in cancer development, cell differentiation and transformation, cell cycle deregulation, and in the expression of tumor-associated genes cannot be ignored. Although Helicobacter pylori activates many oncogenic pathways, particularly those in gastric and colorectal cancers, the role of viruses in tumor development is also significant. Viruses possess significant oncogenic potential to interfere with normal cell cycle control and genome stability, stimulating the growth of deregulated cells. An increasing amount of recent data also implies the association of GI cancers with bacterial colonization and viruses. This review focuses on host-cell interactions that facilitate primary mechanisms of tumorigenesis and provides new insights into novel GI cancer treatments. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|