Sensitivity of unilateral- versus bilateral-onset spike-wave discharges to ethosuximide and carbamazepine in the fluid percussion injury rat model of traumatic brain injury
| Autor: | F. Edward Dudek, Sean Tatum, Zachariah Z. Smith, Jeremy J. Taylor, David Poulsen, Daniel S. Barth |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Physiology Traumatic brain injury Rat model Percussion 03 medical and health sciences Epilepsy 0302 clinical medicine Seizures Brain Injuries Traumatic Medicine Posttraumatic epilepsy Animals Rats Wistar Spike-wave discharges business.industry General Neuroscience 030208 emergency & critical care medicine Carbamazepine medicine.disease Rats Disease Models Animal Ethosuximide Fluid percussion Anesthesia Anticonvulsants Electrocorticography business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of neurophysiology. 125(6) |
| ISSN: | 1522-1598 |
| Popis: | Unilateral-onset spike-wave discharges (SWDs) following fluid percussion injury (FPI) in rats have been used for nearly two decades as a model for complex partial seizures in human posttraumatic epilepsy (PTE). This study determined if SWDs with a unilateral versus bilateral cortical onset differed. In this experiment, 2-mo-old rats received severe FPI (3 atm) or sham surgery and were instrumented for chronic video-electrocorticography (ECoG) recording (up to 9 mo). The antiseizure drug, carbamazepine (CBZ), and the antiabsence drug, ethosuximide (ETX), were administered separately to determine if they selectively suppressed unilateral- versus bilateral-onset SWDs, respectively. SWDs did not significantly differ between FPI and sham rats on any measured parameter (wave-shape, frequency spectrum, duration, or age-related progression), including unilateral (∼17%) versus bilateral (∼83%) onsets. SWDs with a unilateral onset preferentially originated ipsilateral to the craniotomy in both FPI and sham rats, suggesting that the unilateral-onset SWDs were related to surgical injury and not specifically to FPI. ETX profoundly suppressed SWDs with either unilateral or bilateral onsets, and CBZ had no effect on either type of SWD. These results suggest that SWDs with either a unilateral or bilateral onset have a pharmacosensitivity similar to absence seizures and are very different from the complex partial seizures of PTE. Therefore, SWDs with a unilateral onset after FPI are not a model of the complex partial seizures that occur in PTE, and their use for finding new treatments for PTE could be counterproductive, particularly if their close similarity to normal brain oscillations is not acknowledged. |
| Databáze: | OpenAIRE |
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