Screening and risk management solutions for steroidal estrogens in surface and wastewater

Autor: Barbora Javurkova, Valeria Dulio, Selim Ait-Aissa, Cornelia Kienle, Rita Schlichting, Daniel Olbrich, Olivier Perceval, Eliška Sychrová, Michael Gundlach, Peter A. Behnisch, Yves Marneffe, Kees Swart, Antonio Moran Palao, Petr Tusil, Manfred Clara, Sarah Könemann, Carole Chalon, Julia Schwaiger, Sara Valsecchi, Henner Hollert, Mario Carere, Sebastian Buchinger, Beate I. Escher, Georg Reifferscheid, Premysl Soldan, Klára Hilscherová, Brigitte von Danwitz, Etiënne L.M. Vermeirssen, Lomig Leborgne, Christoph Scheffknecht, Eszter Simon, Carolina Di Paolo, Stefano Polesello, Robert Kase, Francesca Bersani, Inge Werner
Přispěvatelé: Ecole Polytechnique Fédérale de Lausanne (EPFL), Research Centre for Toxic Compounds in the Environment [Brno] (RECETOX / MUNI), Faculty of Science [Brno] (SCI / MUNI), Masaryk University [Brno] (MUNI)-Masaryk University [Brno] (MUNI), Rheinisch-Westfälische Technische Hochschule Aachen (RWTH), Helmholtz Zentrum für Umweltforschung = Helmholtz Centre for Environmental Research (UFZ), Institut National de l'Environnement Industriel et des Risques (INERIS), Stress Environnementaux et BIOsurveillance des milieux aquatiques (SEBIO), Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU)-Université de Reims Champagne-Ardenne (URCA)-SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Institut National de l'Environnement Industriel et des Risques (INERIS), Universidad de León [León], Agence Française de la Biodiversité
Jazyk: angličtina
Rok vydání: 2018
Předmět:
010504 meteorology & atmospheric sciences
010501 environmental sciences
01 natural sciences
Analytical Chemistry
[CHIM.ANAL]Chemical Sciences/Analytical chemistry
EU WATCH-LIST
Regulation of chemicals
ENDOCRINE DISRUPTION
Chemical monitoring of Emerging pollutants
Effect-based methods
Endocrine disruption
EU watch-list
Oestrogen screening
Risk-based trigger values
Science-policy interface
Surface and wastewater assessment
Water framework directive
OESTROGEN SCREENING
Spectroscopy
Risk management
Environmental quality
EFFECT-BASED METHODS
0105 earth and related environmental sciences
[SDE.IE]Environmental Sciences/Environmental Engineering
business.industry
6. Clean water
SCIENCE-POLICY INTERFACE
Water Framework Directive
Wastewater
Aquatic environment
CHEMICAL MONITORING OF EMERGING POLLUTANTS
WATER FRAMEWORK DIRECTIVE
ddc:540
RISK-BASED TRIGGER VALUES
Environmental science
[SDV.TOX.ECO]Life Sciences [q-bio]/Toxicology/Ecotoxicology
Water quality
Biochemical engineering
business
Risk assessment
SURFACE AND WASTEWATER ASSESSMENT
Zdroj: Trends in analytical chemistry 102, 343-358 (2018). doi:10.1016/j.trac.2018.02.013
Trends in Analytical Chemistry
Trends in Analytical Chemistry, Elsevier, 2018, 102, pp.343-358. ⟨10.1016/j.trac.2018.02.013⟩
TrAC. Trends in analytical chemistry (Regul. ed.) 102 (2018): 343–358. doi:10.1016/j.trac.2018.02.013
info:cnr-pdr/source/autori:Kase, Robert; Javurkova, Barbora; Simon, Eszter; Swart, Kees; Buchinger, Sebastian; Koenemann, Sarah; Escher, Beate I.; Carere, Mario; Dulio, Valeria; Ait-Aissa, Selim; Hollert, Henner; Valsecchi, Sara; Polesello, Stefano; Behnisch, Peter; di Paolo, Carolina; Olbrich, Daniel; Sychrova, Eliska; Gundlach, Michael; Schlichting, Rita; Leborgne, Lomig; Clara, Manfred; Scheffknecht, Christoph; Marneffe, Yves; Chalon, Carole; Tusil, Petr; Soldan, Premysl; von Danwitz, Brigitte; Schwaiger, Julia; Moran Palao, Antonio; Bersani, Francesca; Perceval, Olivier; Kienle, Cornelia; Vermeirssen, Etienne; Hilscherova, Klara; Reifferscheid, Georg; Werner, Inge/titolo:Screening and risk management solutions for steroidal estrogens in surface and wastewater/doi:10.1016%2Fj.trac.2018.02.013/rivista:TrAC. Trends in analytical chemistry (Regul. ed.)/anno:2018/pagina_da:343/pagina_a:358/intervallo_pagine:343–358/volume:102
ISSN: 0165-9936
Popis: International audience; Background : The European Commission Implementing Decision EU 2015/495 included three steroidal estrogens, namely 17α-ethinyl estradiol, 17β-estradiol, and estrone, in the so-called “watch list” of the EU Water Framework Directive (WFD). The monitoring of these compounds is difficult because the detection limits of the majority of the available analytical methods cannot achieve the very low target concentrations required to meet proposed environmental quality criteria. In 2014, a combined Science-Policy Interface/Chemical Monitoring of Emerging Pollutants project was launched to meet this monitoring challenge. The project involved 24 research organizations and environmental agencies from 12 different countries.Methods : Sixteen surface water (SW) and 17 wastewater (WW) samples were collected across Europe and analysed using five in vitro effect-based and three chemical analytical methods. A general description of the project and data evaluation is provided by Könemann and colleagues in the companion publication 2018. In our study, we compared bioanalytical and chemical analytical results with regard to their application for aquatic status assessment. Therefore we considered the potential to predict population-relevant risks for aquatic organisms and the specificity and sensitivity of the various methods used in both approaches. Finally, we tested and discussed the applicability and relevance of previously suggested effect-based trigger values (EBT).Results and discussion : Results of the risk assessment based on chemical analytical data correlated highly with estrogenic activities (expressed as 17β-estradiol equivalents (EEQ) determined using effect-based methods), demonstrating the ability of the bioassays to predict the mixture risk caused by steroidal estrogens. For about 15% of SW and 40% of WW samples detection limits of chemical-analytical methods were too high to allow a status assessment, while detection limits of all effect-based methods were below proposed EBT. This demonstrates that effect-based methods are suitable for status assessment of surface waters. The in vitro effect-based methods were quite specific for steroidal estrogens and highly sensitive, meaning they have a low probability to detect false positive or negative results. After testing of three alternative EBT proposals, we concluded to use preliminary 400 pg/L EEQ as screening EBT corresponding to the AA-EQS of E2. Further test specific refinements in the application of this value are not excluded.Conclusions : We conclude that water quality assessment can progress from a purely analytical approach to effect-based monitoring, from single substance to known and unknown mixture assessment and from in vitro screening to population-relevant risk assessment. Despite a few limitations, effect-based in vitro methods are recommendable for monitoring steroidal estrogens under the WFD because they, a) are able to sensitively quantify the activity of steroidal estrogens in all surface and wastewater samples, b) are able to detect the combined effect of estrogen mixtures including unknown chemicals with estrogen receptor activating properties, c) allow an ecotoxicological status assessment using EBT to calculate risk quotients. This approach is similar to the risk ratio used in regulatory environmental risk assessments, but allows for an integrated mixture assessment. Outlook : The results of this study support the introduction of a holistic approach for the regulation of chemicals in the aquatic environment under the EU WFD, as proposed recently by EU Water Directors. An ecotoxicological status assessment for one of the most relevant modes of action of endocrine disruption will allow authorities responsible for water quality assessment to focus available monitoring resources and to improve the ecological status of EU waterbodies.
Databáze: OpenAIRE
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