Assessment of treatment response after lung stereotactic body radiotherapy using diffusion weighted magnetic resonance imaging and positron emission tomography: A pilot study
| Autor: | Yukinori Matsuo, Shigeaki Umeoka, Takashi Mizowaki, Yusuke Iizuka, Kaori Togashi, Takashi Shintani, Masahiro Hiraoka, Takamasa Mitsuyoshi, Yuji Nakamoto |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Treatment response Lung Neoplasms medicine.medical_treatment Pilot Projects Radiosurgery 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 Carcinoma Non-Small-Cell Lung medicine Humans Radiology Nuclear Medicine and imaging Stage (cooking) Lung cancer Lung medicine.diagnostic_test business.industry General Medicine medicine.disease medicine.anatomical_structure Diffusion Magnetic Resonance Imaging Positron emission tomography 030220 oncology & carcinogenesis Positron-Emission Tomography Radiology Neoplasm Recurrence Local business Nuclear medicine Stereotactic body radiotherapy Diffusion MRI |
| Zdroj: | European journal of radiology. 92 |
| ISSN: | 1872-7727 |
| Popis: | Background and purpose There is no early predictor of treatment response after lung stereotactic body radiotherapy (SBRT). We conducted this pilot study to evaluate whether serial diffusion weighted magnetic resonance imaging (DW-MRI) or positron emission tomography (PET) could predict response after SBRT. Material and methods Early stage non-small cell lung cancer patients who received SBRT were eligible. DW-MRI and PET were undertaken pretreatment and every 3 months after SBRT in the first year. Patients with max ) of tumors were measured and compared between groups with or without local recurrence (LR). Results Fifteen patients were enrolled and the data of 14 patients were analyzed. The median ADC value was significantly lower in patients with LR (n = 3) than in those without LR (n = 11) at 3 and 6 months (1.11 vs. 1.54 and 0.98 vs. 1.69 [×10 −3 mm 2 /s]; p = 0.039 and 0.012, respectively) while there was no significant difference pretreatment and at 9 and 12 months after treatment. No significant difference was observed in the SUV max at any time point. Conclusions DW-MRI could be an early predictor of treatment response after lung SBRT. |
| Databáze: | OpenAIRE |
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