Neutrophil–lymphocyte ratio (NLR) was associated with prognosis and immunomodulatory in patients with pancreatic ductal adenocarcinoma (PDAC)
| Autor: | Tao Hu, Ning Cui, Hao Wang, Xiang Zijun, Wang Yun, Lin Xu |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Time Factors Neutrophils Lymphocyte medicine.medical_treatment pancreatic cancer Biochemistry Gastroenterology 0302 clinical medicine Risk Factors T-Lymphocyte Subsets IL-2 receptor Diagnostics & Biomarkers Research Articles Cancer Diabetes & Metabolic Disorders Middle Aged Flow Cytometry Progression-Free Survival Phenotype medicine.anatomical_structure 030220 oncology & carcinogenesis Female Carcinoma Pancreatic Ductal medicine.medical_specialty T cell Biophysics Risk Assessment Immunophenotyping 03 medical and health sciences Predictive Value of Tests Pancreatic cancer Internal medicine medicine Humans Antigens Tumor-Associated Carbohydrate Lymphocyte Count Molecular Biology Survival analysis Aged Retrospective Studies Neutrophil-lymphocyte ratio Chemotherapy Receiver operating characteristic business.industry fungi Cell Biology medicine.disease Pancreatic Neoplasms 030104 developmental biology prognosis business CD8 |
| Zdroj: | Bioscience Reports |
| ISSN: | 1573-4935 0144-8463 |
| Popis: | Although the oncological outcomes in patients with pancreatic ductal adenocarcinoma (PDAC) have markedly improved over the past decade, the survival prediction is still challenging. The aim of this study was to investigate the prognostic value of neutrophil–lymphocyte ratio (NLR) and analyze the relationship of between the NLR and immune cells phenotypes in patients with PDAC. Sixty-seven consecutive patients with PDAC were recruited in this study. Life-table estimates of survival time were calculated according to the Kaplan and Meier methodology. The phenotypic T cells subclasses were evaluated by flow cytometry. All the 67 patients in this study were treated with surgical resection and among them, 46 patients received adjuvant chemotherapy. Receiver operating characteristic (ROC) curves analysis was performed to compare prognostic value of NLR with CA199. We found that the Harrell's area under ROC (AUROC) for the NLR to predict overall survival (OS) (0.840; 95% CI, 0.766–0.898) was significantly higher than that of the CA199 levels. After that we stratified all patients into NLR > 2.5 (n = 42) and NLR ≤ 2.5 (n = 25) groups according to the OS of patients with PDAC. Survival analysis showed that patients with NLR ≤ 2.5 had significantly favorable OS and progressive free survival (PFS) compared with patients with NLR > 2.5. The CD3+ and CD8+/CD28+ T cell subsets were significantly increased in patients with NLR ≤ 2.5 (P |
| Databáze: | OpenAIRE |
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