Longitudinal Trajectories of Neurocognitive Functioning in Childhood Acute Lymphoblastic Leukemia
| Autor: | Kathryn M. Russell, Heather M. Conklin, Marita Partanen, Kevin R. Krull, Sean Phipps, Doralina L. Anghelescu, Hiroto Inaba, Joshua Wolf, Lisa M. Jacola, Ching-Hon Pui |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Neuropsychological Tests Logistic regression 03 medical and health sciences Cognition 0302 clinical medicine Memory Survivorship curve Developmental and Educational Psychology Humans Learning Medicine Child Childhood Acute Lymphoblastic Leukemia Aged 030304 developmental biology 0303 health sciences California Verbal Learning Test business.industry Focus on Methodology: Latent Growth Mixture Modeling Neuropsychology Precursor Cell Lymphoblastic Leukemia-Lymphoma Latent class model Clinical trial 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Female Cognition Disorders business Neurocognitive Clinical psychology |
| Zdroj: | J Pediatr Psychol |
| ISSN: | 1465-735X 0146-8693 0013-7111 |
| Popis: | Objective Children with acute lymphoblastic leukemia (ALL) are at risk for neurocognitive deficits, and examining individual variability is essential to understand these risks. This study evaluated latent longitudinal trajectories and risk factors of neurocognitive outcomes in childhood ALL. Methods There were 233 participants with ALL who were enrolled on a phase 3, risk-stratified chemotherapy-only clinical trial (NCT00137111) and who completed protocol-directed neurocognitive assessments [47.6% female, mean (SD) = 6.6 (3.7) years]. Measures of sustained attention, learning/memory, and parent ratings of attention were completed during and after treatment. Longitudinal latent class analyses were used to classify participants into distinct trajectories. Logistic regression was used to identify predictors of class membership. Results Within the overall group, attention performance was below age expectations across time (Conners Continuous Performance Test detectability/variability, p Conclusions Most patients with ALL have stable neurocognitive profiles. Smaller groups have significant impairments shortly after diagnosis or have worsening performance over time. A tiered assessment approach, which includes consideration of individual and clinical risk factors, may be useful for monitoring neurocognitive functioning during treatment and survivorship. |
| Databáze: | OpenAIRE |
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