Quantitative and temporal differential recovery of articular and muscular limitations of knee joint contractures; results in a rat model
| Autor: | Elizabeth Coletta, Odette Laneuville, Hans K. Uhthoff, Louis Goudreau, Guy Trudel |
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| Rok vydání: | 2014 |
| Předmět: |
Male
musculoskeletal diseases medicine.medical_specialty Contracture Knee Joint Physiology Spontaneous recovery Rat model Rats Sprague-Dawley Physiology (medical) Joint capsule medicine Animals Joint Contracture Range of Motion Articular Muscle Skeletal Muscle contracture business.industry Knee flexion contracture Recovery of Function musculoskeletal system Rats Surgery Disease Models Animal medicine.anatomical_structure medicine.symptom business |
| Zdroj: | Journal of Applied Physiology. 117:730-737 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/japplphysiol.00409.2014 |
| Popis: | Joint contractures alter the mechanical properties of articular and muscular structures. Reversibility of a contracture depends on the restoration of the elasticity of both structures. We determined the differential contribution of articular and muscular structures to knee flexion contractures during spontaneous recovery. Rats (250, divided into 24 groups) had one knee joint surgically fixed in flexion for six different durations, from 1 to 32 wk, creating joint contractures of various severities. After the fixation was removed, the animals were left to spontaneously recover for 1 to 48 wk. After the recovery periods, animals were killed and the knee extension was measured before and after division of the transarticular posterior muscles using a motorized arthrometer. No articular limitation had developed in contracture of recent onset (≤2 wk of fixation, P > 0.05); muscular limitations were responsible for the majority of the contracture (34 ± 8° and 38 ± 6°, respectively; both P < 0.05). Recovery for 1 and 8 wk reversed the muscular limitation of contractures of recent onset (1 and 2 wk of fixation, respectively). Long-lasting contractures (≥4 wk of fixation) presented articular limitations, irreversible in all 12 durations of recovery compared with controls (all 12 P < 0.05). Knee flexion contractures of recent onset were primarily due to muscular structures, and they were reversible during spontaneous recovery. Long-lasting contractures were primarily due to articular structures and were irreversible. Comprehensive temporal and quantitative data on the differential reversibility of mechanically significant alterations in articular and muscular structures represent novel evidence on which to base clinical practice. |
| Databáze: | OpenAIRE |
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