Angiogenesis and Multiple Sclerosis Pathogenesis: A Glance at New Pharmaceutical Approaches

Autor:	Maria Teresa Gentile, Gianluca Muto, Giacomo Lus, Karl-Olof Lövblad, Åsa Fex Svenningsen, Luca Colucci-D’Amato
Přispěvatelé:	Gentile, Maria Teresa, Muto, Gianluca, Lus, Giacomo, Lövblad, Karl-Olof, Svenningsen, Åsa Fex, Colucci-D'Amato, Luca
Rok vydání:	2022
Předmět:	multiple sclerosi angiogenesi neuroprotection General Medicine
Zdroj:	Journal of clinical medicine. 11(16)
ISSN:	2077-0383
Popis:	Multiple sclerosis is a chronic disease of the central nervous system characterized by demyelination and destruction of axons. The most common form of the disease is the relapsing-remitting multiple sclerosis in which episodic attacks with typical neurological symptoms are followed by episodes of partial or complete recovery. One of the underestimated factors that contribute to the pathogenesis of multiple sclerosis is excessive angiogenesis. Here, we review the role of angiogenesis in the onset and in the development of the disease, the molecular mechanisms underlying angiogenesis, the current therapeutic approaches, and the potential therapeutic strategies with a look at natural compounds as multi-target drugs with both neuroprotective and anti-angiogenic properties.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40fa8dd5c0f9c7bacd4913852869e1d3 https://pubmed.ncbi.nlm.nih.gov/36012883 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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