D-mannose induces regulatory T cells and suppresses immunopathology
| Autor: | Zi-Jiang Chen, Wenwen Jin, Ruiqing Wu, Qianming Chen, Wanjun Chen, Nathan Goldberg, Cheryl Chia, Lingyun Sun, Hiroko Nakatsukasa, Joanne E. Konkel, Shimpei Kasagi, Peter Zanvit, Dunfang Zhang, Xue Jiao |
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| Rok vydání: | 2017 |
| Předmět: |
Lung Diseases
0301 basic medicine Integrins Adoptive cell transfer Mannose T-Lymphocytes Regulatory Mice chemistry.chemical_compound Mice Inbred NOD Transforming Growth Factor beta Immunopathology Lung Reverse Transcriptase Polymerase Chain Reaction Chemistry Fatty Acids FOXP3 Forkhead Transcription Factors General Medicine Colitis Flow Cytometry Adoptive Transfer Up-Regulation Cell biology medicine.anatomical_structure medicine.symptom Oxidation-Reduction Colon Ovalbumin T cell Inflammation In Vitro Techniques Real-Time Polymerase Chain Reaction General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Immune system Downregulation and upregulation Respiratory Hypersensitivity medicine Animals Humans Pancreas Lipid Metabolism Mice Inbred C57BL Disease Models Animal Diabetes Mellitus Type 1 030104 developmental biology Dietary Supplements Reactive Oxygen Species Spleen |
| Zdroj: | Zhang, D, Chia, C, Jiao, X, Jin, W, Kasagi, S, Wu, R, Konkel, J, Nakatsukasa, H, Zanvit, P, Goldberg, N, Chen, Q, Sun, L, Chen, Z-J & Chen, W J 2017, ' D-mannose induces regulatory T cells and suppresses immunopathology ', Nature Medicine, vol. 23, pp. 1036-1045 . https://doi.org/10.1038/nm.4375 |
| ISSN: | 1546-170X 1078-8956 |
| Popis: | D-mannose, a C-2 epimer of glucose, exists naturally in many plants and fruits, and is found in human blood at concentrations less than one-fiftieth of that of glucose. However, although the roles of glucose in T cell metabolism, diabetes and obesity are well characterized, the function of D-mannose in T cell immune responses remains unknown. Here we show that supraphysiological levels of D-mannose safely achievable by drinking-water supplementation suppressed immunopathology in mouse models of autoimmune diabetes and airway inflammation, and increased the proportion of Foxp3+ regulatory T cells (Treg cells) in mice. In vitro, D-mannose stimulated Treg cell differentiation in human and mouse cells by promoting TGF-β activation, which in turn was mediated by upregulation of integrin αvβ8 and reactive oxygen species generated by increased fatty acid oxidation. This previously unrecognized immunoregulatory function of D-mannose may have clinical applications for immunopathology. |
| Databáze: | OpenAIRE |
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