The neuroendocrine response to stress under the effect of drugs: Negative synergy between amphetamine and stressors

Autor: Xavier Belda, Almudena Gómez-Román, Juan A. Ortega-Sánchez, Ignacio Marín-Blasco, Antonio Armario, Roser Nadal, Humberto Gagliano, David Rotllant, Raul Delgado-Morales
Rok vydání: 2016
Předmět:
Blood Glucose
Male
Restraint
Physical
0301 basic medicine
Hypothalamo-Hypophyseal System
endocrine system
medicine.medical_specialty
Corticotropin-Releasing Hormone
Endocrinology
Diabetes and Metabolism
Interleukin-1beta
Pituitary-Adrenal System
Adrenocorticotropic hormone
03 medical and health sciences
chemistry.chemical_compound
Corticotropin-releasing hormone
0302 clinical medicine
Endocrinology
Adrenocorticotropic Hormone
Corticosterone
Internal medicine
medicine
Animals
Amphetamine
Swimming
Biological Psychiatry
Endocrine and Autonomic Systems
Drug Synergism
Rats
Psychiatry and Mental health
030104 developmental biology
medicine.anatomical_structure
chemistry
Hypothalamus
Central Nervous System Stimulants
Psychology
Proto-Oncogene Proteins c-fos
Stress
Psychological
hormones
hormone substitutes
and hormone antagonists
030217 neurology & neurosurgery
Hypothalamic–pituitary–adrenal axis
Paraventricular Hypothalamic Nucleus
Behavioural despair test
Hormone
medicine.drug
Zdroj: Psychoneuroendocrinology. 63:94-101
ISSN: 0306-4530
Popis: There have been numerous studies into the interaction between stress and addictive drugs, yet few have specifically addressed how the organism responds to stress when under the influence of psychostimulants. Thus, we studied the effects of different acute stressors (immobilization, interleukin-1β and forced swimming) in young adult male rats simultaneously exposed to amphetamine (AMPH, 4 mg/kg SC), evaluating classic biological markers. AMPH administration itself augmented the plasma hypothalamic-pituitary-adrenal (HPA) hormones, adrenocorticotropin (ACTH) and corticosterone, without affecting plasma glucose levels. By contrast, this drug dampened the peripheral HPA axis, as well as the response of glucose to the three stressors. We also found that AMPH administration completely blocked the forced swim-induced expression of the corticotropin-releasing hormone (hnCRH) and it partially reduced c-fos expression in the paraventricular nucleus of the hypothalamus (PVN). Indeed, this negative synergy in the forced swim test could even be observed with a lower dose of AMPH (1mg/kg, SC), a dose that is usually received in self-administration experiments. In conclusion, when rats that receive AMPH are subjected to stress, a negative synergy occurs that dampens the prototypic peripheral physiological response to stress and activation of the PVN.
Databáze: OpenAIRE
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