Four New Gallate Derivatives from Wine-Processed Corni Fructus and Their Anti-Inflammatory Activities
| Autor: | Er-Ping Xu, Jun Chi, Hong-Bin Li, Jing Wang, Li-Ping Dai, Zhang Lingxia, Qing-Mei Feng, Sui-Qing Chen, Zhi-Min Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Lipopolysaccharides
medicine.drug_class Anti-Inflammatory Agents Pharmaceutical Science 010403 inorganic & nuclear chemistry Nitric Oxide 01 natural sciences Anti-inflammatory Article Analytical Chemistry lcsh:QD241-441 Mice Cornus lcsh:Organic chemistry Gallic Acid Drug Discovery medicine Animals Physical and Theoretical Chemistry No production anti-inflammatory activity Wine biology Traditional medicine 010405 organic chemistry Chemistry Corni Fructus Spectroscopy methods Organic Chemistry Gallate Cornus officinalis biology.organism_classification In vitro 0104 chemical sciences RAW 264.7 Cells Chemistry (miscellaneous) Fruit gallate derivatives Molecular Medicine wine-processed Corni fructus |
| Zdroj: | Molecules Molecules, Vol 26, Iss 1851, p 1851 (2021) Volume 26 Issue 7 |
| ISSN: | 1420-3049 |
| Popis: | Four new gallate derivatives—ornusgallate A, ent-cornusgallate A, cornusgallate B and C (1a, 1b, 2, 3)—were isolated from the wine-processed fruit of Cornus officinalis. Among them, 1a and 1b are new natural compounds with novel skeletons. Their chemical structures were elucidated by comprehensive spectroscopy methods including NMR, IR, HRESIMS, UV, ECD spectra and single-crystal X-ray diffraction analysis. The in vitro anti-inflammatory activities of all compounds were assayed in RAW 264.7 cells by assessing LPS-induced NO production. As the result, all compounds exhibited anti-inflammatory activities at attested concentrations. Among the tested compounds, compound 2 exhibited the strongest anti- inflammatory activity. |
| Databáze: | OpenAIRE |
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