Zinc deficiency limiting head growth to discharge in extremely low gestational age infants with insufficient linear growth: a cohort study
| Autor: | L. Steven Brown, Audrey Edwards, Patti J. Burchfield, Roy J. Heyne, Cheryl S. Lair, Luc P. Brion, Maria Caraig |
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| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_element
Physiology Gestational Age Zinc Cohort Studies 03 medical and health sciences Child Development 0302 clinical medicine 030225 pediatrics medicine Humans 030212 general & internal medicine Retrospective Studies business.industry Postmenstrual Age Infant Obstetrics and Gynecology Gestational age Retrospective cohort study medicine.disease Patient Discharge chemistry Pediatrics Perinatology and Child Health Cohort Zinc deficiency medicine.symptom business Weight gain Cohort study |
| Zdroj: | Journal of Perinatology. 40:1694-1704 |
| ISSN: | 1476-5543 0743-8346 |
| DOI: | 10.1038/s41372-020-00778-w |
| Popis: | To assess the relationship of size for age with zinc deficiency in extremely low gestational age (GA) infants (23-28 weeks, ELGANs) who had insufficient linear growth despite optimizing other nutrients and to analyze changes in fronto-occipital circumference (FOC), weight and length with zinc supplementation.Retrospective cohort study.Among 302 ELGANs, a serum zinc concentration was obtained in 52 with insufficient linear growth (17%). Zinc deficiency (serum concentration0.74 mcg/ml) was diagnosed in 8 of 24 (33%) small for GA (SGA) compared to 35 of 278 (13%) non-SGA infants (P = 0.01). Zinc supplementation for2 weeks improved FOC growth to discharge or 50 weeks postmenstrual age in infants with Zn deficiency. However, neither linear growth nor weight gain improved with Zn supplementation.Zinc deficiency was diagnosed in 14% ELGANs in this cohort. Zinc supplementation for2 weeks improved FOC growth but not linear growth or weight gain. |
| Databáze: | OpenAIRE |
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