Synthesis and Cytotoxic Activity of Chiral Sulfonamides Based on the 2-Azabicycloalkane Skeleton

Autor:	Elżbieta Wojaczyńska, Daniel Senfter, Matthias Pinter, Nataliya Rohr-Udilova, Jacek Wojaczyński, Dominika Iwan, Andrzej Kochel, Mahzeiar Samadaei, Sibylle Madlener, Karolina Kamińska
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Carcinoma Hepatocellular Stereochemistry Pharmaceutical Science 010402 general chemistry 01 natural sciences Article Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound lcsh:Organic chemistry Azepane Drug Discovery Alkanes medicine Cytotoxic T cell Humans Viability assay Physical and Theoretical Chemistry Amines neoplasms cytotoxic activity Sulfonyl chemistry.chemical_classification Sulfonamides Bicyclic molecule Molecular Structure 010405 organic chemistry Organic Chemistry Liver Neoplasms 2-azabicycloalkane chiral sulfonamide Stereoisomerism medicine.disease Skeleton (computer programming) 0104 chemical sciences chemistry Chemistry (miscellaneous) Cell culture Molecular Medicine Glioblastoma
Zdroj:	Molecules Volume 25 Issue 10 Molecules, Vol 25, Iss 2355, p 2355 (2020)
ISSN:	1420-3049
Popis:	A series of chiral sulfonamides containing the 2-azabicycloalkane scaffold were prepared from aza-Diels&ndash Alder cycloadducts through their conversion to amines based on 2-azanorbornane or the bridged azepane skeleton, followed by the reaction with sulfonyl chlorides. The cytotoxic activity of the obtained bicyclic derivatives was evaluated using human hepatocellular carcinoma (HCC), medulloblastoma (MB), and glioblastoma (GBM) cell lines. Chosen compounds were shown to notably reduce cell viability as compared to nonmalignant cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f55b5e45fb0fcb86f1f88d51b3fca6 http://europepmc.org/articles/PMC7288168 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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